Evidence map›Paper›PMID 28465651›Full record

ArticleEthiopian journal of health sciences2017

Factors Associated with Mortality of TB/HIV Co-infected Patients in Ethiopia.

Alula M Teklu, Abiy Nega, Admasu Tenna Mamuye, Yohannes Sitotaw, Desta Kassa, Getnet Mesfin, Bekele Belayihun, Girmay Medhin, Kesetebirhan Yirdaw

Open access · diamondAbstract read
In one paragraph

Article in Ethiopian journal of health sciences, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed, 5 pooled it
2.3field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 5 syntheses or guidelines pooled it, 49 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Pooled it
  6. Trial
  7. Article
  8. Article
  9. Article
  10. Article
  11. Review
  12. Vaccines · 2024
    Review
  13. Article
  14. Article
  15. Review
  16. Article
  17. Article
  18. Impact of HIV-AIDS on tuberculosis treatment outcome in Southern Ethiopia - A retrospective cohort study.Journal of clinical tuberculosis and other mycobacterial diseases · 2021
    Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 1 country.

Alula M TekluAlula M. Teklu: MERQ Consultancy Services, Addis Ababa, Ethiopa.
Abiy NegaAbiy Nega: MERQ Consultancy Services, Addis Ababa, Ethiopia.
Admasu Tenna MamuyeAdmasu Tenna Mamuye: Addis Ababa University, Medical Faculty, Addis Ababa, Ethiopia.
Yohannes SitotawYohannes Sitotaw: Ministry of Science and Technology, Addis Ababa, Ethiopia.
Desta KassaDesta Kassa: Ethiopian Public Health Institute, Addis Ababa, Ethiopia.
Getnet MesfinGetnet Mesfin: Ethiopian Public Health Institute, Addis Ababa, Ethiopia.
Bekele BelayihunMekele Belayhiun: Ethiopian Public Health Association, Addis Ababa, Ethiopia.
Girmay MedhinGirmay Medhin: Aklilu Lemma Institute of Pathobiology, Addis Ababa.
Kesetebirhan YirdawKesetebirhan Delele: South Africa University, Addis Ababa, Ethiopia.
Ethiopian Public Health Institute · ETAddis Ababa University · ETEthiopian Public Health Association · ETGeoSAS (Ethiopia) · ET

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundDespite the large number of TB patients on ART in Ethiopia, their mortality remains high. This study reports the effect of TB on HIV related mortality and determinants of TB/HIV co-infection related mortality.

methodsA longitudinal study design was employed as part of the Advanced Clinical Monitoring of ART (ACM) in Ethiopia. All patients started on ART at or after January 1, 2005 were included. Survival analysis was done to compare survival patterns of HIV patients with TB against HIV patients without TB. In addition, determinants of survival among TB/HIV co-infected patients were analyzed. Adjusted effects of the different factors on time to death were generated using Cox-proportional hazards regression.

resultsA total of 3,889 patients were enrolled in the ACM study, of which 355 TB cases were identified, making the crude prevalence 9% (95% CI 8.3 - 10.2). Overall, incidence of TB was 2.2 (95% CI 1.9-2.4) per 100 person-years. TB was highest in the first 2 months and declined with time on ART to reach 1 per 100 person years after 24 months on ART. TB was significantly associated with mortality among HIV patients on HAART (AHR 2.0, 95% CI 1.47-2.75). Male gender was associated with mortality among TB/HIV co-infected patients.

conclusionTuberculosis plays a key role in HIV associated mortality. Targeted interventions which can keep patients free of TB in the early stages of their treatment are required to reduce TB related mortality.

Indexed as

AdolescentAdultAnti-HIV AgentsAntiretroviral Therapy, Highly ActiveCoinfectionEthiopiaFemaleHIV InfectionsHumansIncidenceLongitudinal StudiesMalePrevalenceProportional Hazards ModelsTuberculosisYoung AdultAnti-HIV AgentsAntiretroviral therapyMortalityTuberculosis

Identifiers

PMID28465651
PMCPMC5402803
OpenAlexW2593973787

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.