Observational studyWorld journal of gastroenterology2017
Impact of vitamin D on the hospitalization rate of Crohn's disease patients seen at a tertiary care center.
Observational study in World journal of gastroenterology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
5 citing papers in PubMed, 12 citations in OpenAlex.
- Sarcopenia and Vitamin D Deficiency in Patients with Crohn's Disease: Pathological Conditions That Should Be Linked Together.Nutrients · 2021Review
- Potential Vaccines for Treating Crohn's DiseaseIranian biomedical journal · 2020Review
- Influence of Vitamin D Deficiency on Inflammatory Markers and Clinical Disease Activity in IBD Patients.Nutrients · 2019Article
- Nutritional status as a predictor of hospitalization in inflammatory bowel disease: A review.World journal of gastrointestinal pharmacology and therapeutics · 2019Review
- The Role of Vitamin D in Elderly Inflammatory Bowel Disease Patients.Gastroenterology & hepatology · 2019Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimTo study the association between vitamin D level and hospitalization rate in Crohn's disease (CD) patients.
methodsWe designed a retrospective cohort study using adult patients (> 19 years) with CD followed for at least one year at our inflammatory bowel disease center. Vitamin D levels were divided into: low mean vitamin D level (< 30 ng/mL)
resultsOf the 880 CD patients, 196 patients with vitamin D level during the observation period were included. Partially adjusted model demonstrated that CD patients with a low mean vitamin D level were almost twice more likely to be admitted (IRR = 1.76, 95%CI: 1.38-2.24) compared to those with an appropriate vitamin D level. The fully adjusted model confirmed this association (IRR = 1.44, 95%CI: 1.11-1.87). Partially adjusted model with vitamin D level as a continuous variable demonstrated, higher mean vitamin D level was associated with a 3% lower likelihood of admission with every unit (ng/mL) rise in mean vitamin D level (IRR = 0.97, 95%CI: 0.96-0.98). The fully adjusted model confirmed this association (IRR = 0.98, 95%CI: 0.97-0.99).
conclusionNormal or adequate vitamin D stores may be protective in the clinical course of CD. However, this role needs to be further characterized and understood.
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Registered trials
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