ArticleOncotarget2017
Clinical and biological features of neuroblastic tumors: A comparison of neuroblastoma and ganglioneuroblastoma.
Article in Oncotarget, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
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Who cites it
40 citing papers in PubMed, 66 citations in OpenAlex.
- Life-Threatening Gastrointestinal Bleeding Revealing a Rare Coexistence of Ampullary Ganglioneuroma and Pancreatic Neuroendocrine Tumor: A Case Report.Diagnostics (Basel, Switzerland) · 2026Article
- Approach to the Preoperative Pharmacological Management of Catecholamine-Secreting Tumors in Children: A Case Series and Review.The journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAG · 2026Article
- The diagnostic value of enhanced CT radiomics and deep learning in differentiating pediatric peripheral neuroblastoma from ganglioneuroblastoma.BMC cancer · 2026Article
- Adult adrenal ganglioneuroblastoma with an extensive metastasis of the skull: case report and review of the literature.Frontiers in oncology · 2026Article
- Rare mandibular metastasis of neuroblastoma in a child: a case report.Frontiers in dental medicine · 2026Article
- A clinically annotated transcriptomic atlas of nervous system tumors.Neuro-oncology · 2025Article
- Stereotactic radiosurgery for brain metastases secondary to adrenal ganglioneuroblastoma: illustrative case.Journal of neurosurgery. Case lessons · 2025Article
- Neuropeptide Y in cancer-biological functions and potential clinical implications.Cancer metastasis reviews · 2025Review
- Combinatorial immunotherapy of anti-MCAM CAR-modified expanded natural killer cells and NKTR-255 against neuroblastoma.Molecular therapy. Oncology · 2024Article
- Cervical Ganglio-neuroma, a Rare Neck Mass in Pediatric Age: A Case Report.Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India · 2024Article
- Characterisation of Paediatric Neuroblastic Tumours by Quantitative Structural and Diffusion-Weighted MRI.Journal of clinical medicine · 2024Article
- Molecular profiling of core immune-escape genes highlights TNFAIP3 as an immune-related prognostic biomarker in neuroblastoma.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2024Article
- Development and validation of a prognostic nomogram for patients with ganglioneuroblastoma: A SEER-based study.Heliyon · 2024Article
- Prediction of High-Risk Neuroblastoma Among Neuroblastic Tumors Using Radiomics Features Derived from Magnetic Resonance Imaging: A Pilot Study.Yonsei medical journal · 2024Article
- Adrenal ganglioneuroblastoma with metastasis near the renal hilum in an adult female: A case report and review of the literature.Oncology letters · 2024Article
- A needle in the haystack: An unusual case presentation of ganglioneuroblastoma at a tertiary care center in Coastal Karnataka.Clinical case reports · 2023Article
- Nonspecific Gastrointestinal Symptoms as the First Sign of Ganglioneuroblastoma Intermixed-Case Report and Literature Review.Journal of clinical medicine · 2023Review
- Ganglioneuroblastoma intermixed: Clinicopathological implications of diagnosis at presentation and genomic correlations.Pediatric blood & cancer · 2023Article
- Computer-assisted rescue of the inferior mesenteric artery in a child with a giant ganglioneuroblastoma: A case report.World journal of gastrointestinal surgery · 2023Article
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Neuroblastoma (NB), ganglioneuroblastoma intermixed (GNBi) and ganglioneuroblastoma nodular (GNBn) are neuroblastic tumors that present with a wide range of symptoms and variable prognoses. We retrospectively reviewed the pretreatment clinical (age, sex and tumor stage) and biological (MYCN amplification; and levels of lactate dehydrogenase, ferritin and neuron-specific enolase) characteristics of 279 patients who were diagnosed with pathologically confirmed NB and GNB from January 2005 to December 2015. The median age at diagnosis increased with grade of differentiation (NB: 28.9 months; GNBn: 38.4 months; GNBi: 47.5 months; p < 0.01). NB patients were more frequently diagnosed with adrenal tumors and had a higher prevalence of abnormal serum ferritin at the time of diagnosis (60.0% vs. 40.0% vs. 12.0%, P<0.001), NSE (96.0% vs. 93.0% vs. 81.0%, P=0.013) when compared with GNBn and GNBi patients. The prevalence rates of disseminated tumors and MYCN amplified tumors were lower in the GNBi group than in the GNBn and NB groups (13.0% vs. 25.0% vs. 44.0%, P=0.002; 0 vs. 14.0% vs. 26.0%, P=0.032, respectively). The overall survival (OS) of patients with GNB was significantly better than that of patients with NB (GNBi: 100%, GNBn: 74.5±11.4%, NB: 50.8±4.5%, respectively; P<0.01). Our study revealed that both NB and GNB have a wide range of presentations, and clinicians should be aware of both typical and atypical symptoms and signs. Children with GNB (especially GNBi) were more likely to present favorable prognostic factors than their NB counterparts, which consequently lead to better outcomes and longer survival for these patients.
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