Evidence map›Paper›PMID 28465449›Full record

Observational studyJournal of clinical pathology2017

Characteristics associated with requests by pathologists for second opinions on breast biopsies.

Berta M Geller, Heidi D Nelson, Donald L Weaver, Paul D Frederick, Kimberly H Allison, Tracy Onega, Patricia A Carney, Anna N A Tosteson, Joann G Elmore

Abstract readObservational Study
In one paragraph

Observational study in Journal of clinical pathology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Berta M GellerDepartment of Family Medicine, University of Vermont, Burlington, Vermont, USA.
Heidi D NelsonDepartments of Medical Informatics and Clinical Epidemiology and Medicine, Oregon Health & Science University; and Providence Cancer Center, Portland, Oregon, USA.
Donald L WeaverDepartment of Pathology, University of Vermont and UVM Cancer Center, Burlington, Vermont, USA.
Paul D FrederickDepartment of Medicine, University of Washington, Seattle, Washington, USA.
Kimberly H AllisonDepartment of Pathology, Stanford University School of Medicine, Stanford, California, USA.
Tracy OnegaDepartments of Biomedical Data Science and Epidemiology, Norris Cotton Cancer Center and The Dartmouth Institute for Health Policy and Clinical Practice, Geisel School of Medicine at Dartmouth, One Medical Center Drive, Lebanon, New Hampshire, USA.
Patricia A CarneyDepartment of Family Medicine, Oregon Health & Science University, Portland, Oregon, USA.
Anna N A TostesonNorris Cotton Cancer Center and The Dartmouth Institute for Health Policy and Clinical Practice, Geisel School of Medicine at Dartmouth, One Medical Center Drive, Lebanon, New Hampshire, USA.
Joann G ElmoreDepartment of Medicine, University of Washington, Seattle, Washington, USA.

Funding

Translational Engineering in Cancer (TEC)P30CA023108 · NCI · DARTMOUTH COLLEGE · PI Steven D Leach · 1985 to 2026
$91.3M
VERMONT BREAST CANCER SURVEILLANCE SYSTEMU01CA070013 · NCI · UNIVERSITY OF VERMONT &ST AGRIC COLLEGE · PI GELLER, BERTA M · 1995 to 2011
$6.7M
STRATEGIC STUDIES IN BREAST CANCER SURVEILLANCEU01CA086082 · NCI · DARTMOUTH COLLEGE · PI ONEGA, TRACY · 2000 to 2011
$4.9M
Accuracy of Breast Pathology and the Impact of Double ReadingR01CA140560 · NCI · UNIVERSITY OF WASHINGTON · PI ELMORE, JOANN G, WEAVER, DONALD LEE · 2009 to 2013
$3.3M
Digital Pathology_Accuracy Viewing Behavior and Image CharacterizationR01CA172343 · NCI · UNIVERSITY OF WASHINGTON · PI SHAPIRO, LINDA, WEAVER, DONALD LEE · 2013 to 2017
$3.2M
NCI NIH HHS P30 CA023108NCI NIH HHS R01 CA140560NCI NIH HHS R01 CA172343NCI NIH HHS U01 CA070013NCI NIH HHS U01 CA086082
6 · The paper itself

Abstract

aimsSecond opinions in pathology improve patient safety by reducing diagnostic errors, leading to more appropriate clinical treatment decisions. Little objective data are available regarding the factors triggering a request for second opinion despite second opinion consultations being part of the diagnostic system of pathology. Therefore we sought to assess breast biopsy cases and interpreting pathologists characteristics associated with second opinion requests.

methodsCollected pathologist surveys and their interpretations of 60 test set cases were used to explore the relationships between case characteristics, pathologist characteristics and case perceptions, and requests for second opinions. Data were evaluated by logistic regression and generalised estimating equations.

results115 pathologists provided 6900 assessments; pathologists requested second opinions on 70% (4827/6900) of their assessments 36% (1731/4827) of these would not have been required by policy. All associations between case characteristics and requesting second opinions were statistically significant, including diagnostic category, breast density, biopsy type, and number of diagnoses noted per case. Exclusive of institutional policies, pathologists wanted second opinions most frequently for atypia (66%) and least frequently for invasive cancer (20%). Second opinion rates were higher when the pathologist had lower assessment confidence, in cases with higher perceived difficulty, and cases with borderline diagnoses.

conclusionsPathologists request second opinions for challenging cases, particularly those with atypia, high breast density, core needle biopsies, or many co-existing diagnoses. Further studies should evaluate whether the case characteristics identified in this study could be used as clinical criteria to prompt system-level strategies for mandating second opinions.

Indexed as

BiopsyPathologistsReferral and ConsultationAdultAgedAttitude of Health PersonnelBreastBreast DiseasesClinical CompetenceCross-Sectional StudiesDiagnosis, DifferentialDiagnostic ErrorsFemaleHealth Knowledge, Attitudes, PracticeHumansLogistic ModelsBREAST CANCERBREAST PATHOLOGYDIAGNOSISLABORATORY MANAGEMENT

Identifiers

PMID28465449
PMCPMC5849252

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.