Evidence map›Paper›PMID 28465443›Full record

Trial reportClinical cancer research : an official journal of the American Association for Cancer Research2017

Phase I and Preliminary Phase II Study of TRC105 in Combination with Sorafenib in Hepatocellular Carcinoma.

Austin G Duffy, Chi Ma, Susanna V Ulahannan, Osama E Rahma, Oxana Makarova-Rusher, Liang Cao, Yunkai Yu, David E Kleiner, Jane Trepel, Min-Jung Lee and 9 more

Open access · hybridAbstract readClinical Trial, Phase IClinical Trial, Phase II
In one paragraph

Trial report in Clinical cancer research : an official journal of the American Association for Cancer Research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 58 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
58citing papers in PubMed, 1 pooled it
3.6field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

58 citing papers in PubMed, 1 synthesis or guideline pooled it, 76 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Trial
  4. Article
  5. Article
  6. Article
  7. Review
  8. Review
  9. Review
  10. Review
  11. CD105: tumor diagnosis, prognostic marker and future tumor therapeutic target.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2022
    Review
  12. Generation ofActa pharmaceutica Sinica. B · 2022
    Article
  13. Article
  14. Article
  15. Review
  16. Review
  17. TGF-β superfamily co-receptors in cancer.Developmental dynamics : an official publication of the American Association of Anatomists · 2022
    Review
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 3 institutions in 1 country.

Austin G DuffyGastrointestinal Malignancies Section, Thoracic-GI Oncology Branch, Center for Cancer Research, NCI, Bethesda, Maryland. duffya@mail.nih.gov tim.greten@nih.gov.
Chi MaGastrointestinal Malignancies Section, Thoracic-GI Oncology Branch, Center for Cancer Research, NCI, Bethesda, Maryland.
Susanna V UlahannanGastrointestinal Malignancies Section, Thoracic-GI Oncology Branch, Center for Cancer Research, NCI, Bethesda, Maryland.
Osama E RahmaGastrointestinal Malignancies Section, Thoracic-GI Oncology Branch, Center for Cancer Research, NCI, Bethesda, Maryland.
Oxana Makarova-RusherGastrointestinal Malignancies Section, Thoracic-GI Oncology Branch, Center for Cancer Research, NCI, Bethesda, Maryland.
Liang CaoGenetics Branch, Center for Cancer Research, NIH, Bethesda, Maryland.
Yunkai YuGenetics Branch, Center for Cancer Research, NIH, Bethesda, Maryland.
David E KleinerLaboratory of Pathology, Center for Cancer Research, NIH, Bethesda, Maryland.
Jane TrepelDevelopmental Therapeutics Branch, Center for Cancer Research, NIH, Bethesda, Maryland.
Min-Jung LeeDevelopmental Therapeutics Branch, Center for Cancer Research, NIH, Bethesda, Maryland.
Yusuke TomitaDevelopmental Therapeutics Branch, Center for Cancer Research, NIH, Bethesda, Maryland.
Seth M SteinbergBiostatistics and Data Management Section, Center for Cancer Research, NIH, Bethesda, Maryland.
Theo HellerLiver Diseases Branch, NIDDK, NIH, Bethesda, Maryland.
Baris TurkbeyMolecular Imaging Program, Center for Cancer Research, NIH, Bethesda, Maryland.
Peter L ChoykeMolecular Imaging Program, Center for Cancer Research, NIH, Bethesda, Maryland.
Cody J PeerClinical Pharmacology Program, Center for Cancer Research, NCI, NIH, Bethesda, Maryland.
William D FiggClinical Pharmacology Program, Center for Cancer Research, NCI, NIH, Bethesda, Maryland.
Brad J WoodRadiology and Imaging Sciences, Center for Cancer Research, NIH, Bethesda, Maryland.
Tim F GretenGastrointestinal Malignancies Section, Thoracic-GI Oncology Branch, Center for Cancer Research, NCI, Bethesda, Maryland. duffya@mail.nih.gov tim.greten@nih.gov.
Center for Cancer Research · USNational Cancer Institute · USNational Institutes of Health · US

Funding

Investigation of management and disease manifestations of viral hepatitisZIADK054514 · NIDDK · NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES · PI HELLER, THEO · 2009 to 2025
$12.9M
Clinical protocols for the treatment of GI cancerZIABC011343 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI GRETEN, TIM · 2010 to 2025
$4.8M
Interventional OncologyZIACL040015 · CLC · CLINICAL CENTER · PI WOOD, BRADFORD · 2009 to 2025
$0k
Intramural NIH HHS Z99 CA999999
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

AdolescentAdultAgedAnimalsAntibodies, MonoclonalAntineoplastic Combined Chemotherapy ProtocolsCarcinoma, HepatocellularCell Line, TumorDisease-Free SurvivalEpistaxisFemaleHeadacheHumansLiver NeoplasmsLiver Neoplasms, ExperimentalMice, Inbred BALB CAntibodies, MonoclonalcarotuximabNiacinamidePhenylurea CompoundsSorafenib

Identifiers

PMID28465443
PMCPMC6640149
OpenAlexW2610302449

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.