Trial reportProceedings of the National Academy of Sciences of the United States of America2017
Brain connectivity dynamics during social interaction reflect social network structure.
Trial report in Proceedings of the National Academy of Sciences of the United States of America, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 71 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
71 citing papers in PubMed, 2 syntheses or guidelines pooled it, 154 citations in OpenAlex.
- Brain computer interfaces for cognitive enhancement in older people - challenges and applications: a systematic review.BMC geriatrics · 2025Pooled it
- Social exclusion reliably engages the default network: A meta-analysis of Cyberball.NeuroImage · 2021Pooled it
- Oxytocin Reduces Subjective Fear in Naturalistic Social Contexts via Enhancing Top-Down Middle Cingulate Amygdala Regulation and Brain-Wide Fear Representations.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Trial
- Examining speakers' subjective and bio-behavioral responses to audience-induced social-evaluative threat via immersive VR.Scientific reports · 2026Article
- Immersive virtual reality as a novel approach to improve social cognition in multiple sclerosis: an EEG-based pilot study.Frontiers in neuroscience · 2026Article
- Brain network efficiency during social interaction is associated with real-world social network size.Behavioral and brain functions : BBF · 2025Article
- Neural similarity and interaction success in autistic and non-autistic adolescents.Scientific reports · 2025Article
- The dynamic relationship of brain-derived neurotrophic factor and oxytocin: Introducing the concept of neurosocial plasticity.Neuroprotection (Chichester, England) · 2025Review
- Intrinsic functional connectivity brain networks mediate effect of age on sociability.PloS one · 2025Article
- Intensive Longitudinal Social Sensing in Patients With Psychosis Spectrum Disorders: An Exploratory Pilot Study.Schizophrenia bulletin · 2024Article
- Promoting mental health in higher education: towards a model of well-being factors in emerging adulthood.International journal of qualitative studies on health and well-being · 2024Review
- Diverse social media experiences and adolescents' depressive symptoms: the moderating role of neurobiological responsivity to rejected peers.Social cognitive and affective neuroscience · 2024Article
- Task-dependent functional connectivity changes in response to varying levels of social support.BJPsych open · 2024Article
- Differences in regional brain structure in toddlers with autism are related to future language outcomes.Nature communications · 2024Article
- Psychophysiological distinctions in emotional responding: sensitivity to perceiving loss of connection.Frontiers in human neuroscience · 2024Article
- Stability and variation of brain-behavior correlation patterns across measures of social support.Imaging neuroscience (Cambridge, Mass.) · 2024Article
- Sports promote brain evolution: a resting-state fMRI study of volleyball athlete.Frontiers in sports and active living · 2024Article
- Directed causal effect with PCMCI in hyperscanning EEG time series.Frontiers in neuroscience · 2024Article
- Neural tracking of social hierarchies in adolescents' real-world social networks.Social cognitive and affective neuroscience · 2023Article
- Social Network Characteristics and Depressive Symptoms of Italian Public Health Medical Residents: The Public Health Residents' Anonymous Survey in Italy (PHRASI).Behavioral sciences (Basel, Switzerland) · 2023Article
11 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 4 institutions in 1 country.
Funding
Abstract
Social ties are crucial for humans. Disruption of ties through social exclusion has a marked effect on our thoughts and feelings; however, such effects can be tempered by broader social network resources. Here, we use fMRI data acquired from 80 male adolescents to investigate how social exclusion modulates functional connectivity within and across brain networks involved in social pain and understanding the mental states of others (i.e., mentalizing). Furthermore, using objectively logged friendship network data, we examine how individual variability in brain reactivity to social exclusion relates to the density of participants' friendship networks, an important aspect of social network structure. We find increased connectivity within a set of regions previously identified as a mentalizing system during exclusion relative to inclusion. These results are consistent across the regions of interest as well as a whole-brain analysis. Next, examining how social network characteristics are associated with task-based connectivity dynamics, we find that participants who showed greater changes in connectivity within the mentalizing system when socially excluded by peers had less dense friendship networks. This work provides insight to understand how distributed brain systems respond to social and emotional challenges and how such brain dynamics might vary based on broader social network characteristics.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.