Evidence map›Paper›PMID 28465432›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2017

Different phosphoisoforms of RNA polymerase II engage the Rtt103 termination factor in a structurally analogous manner.

Corey M Nemec, Fan Yang, Joshua M Gilmore, Corinna Hintermair, Yi-Hsuan Ho, Sandra C Tseng, Martin Heidemann, Ying Zhang, Laurence Florens, Audrey P Gasch and 4 more

Open access · bronzeAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
1.6field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 34 citations in OpenAlex.

  1. Review
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  6. ThrScience advances · 2024
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  18. TheeLife · 2019
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 4 institutions in 2 countries.

Corey M NemecDepartment of Biochemistry, University of Wisconsin-Madison, Madison, WI 53706.ORCID 0000-0002-6566-1753
Fan YangDepartment of Chemistry, University of Washington, Seattle, WA 98195.
Joshua M GilmoreStowers Institute for Medical Research, Kansas City, MO 64110.
Corinna HintermairDepartment of Molecular Epigenetics, Helmholtz Center Munich, Center for Integrated Protein Science, 81377 Munich, Germany.
Yi-Hsuan HoLaboratory of Genetics, University of Wisconsin-Madison, Madison, WI 53706.
Sandra C TsengDepartment of Biochemistry, University of Wisconsin-Madison, Madison, WI 53706.
Martin HeidemannDepartment of Molecular Epigenetics, Helmholtz Center Munich, Center for Integrated Protein Science, 81377 Munich, Germany.
Ying ZhangStowers Institute for Medical Research, Kansas City, MO 64110.
Laurence FlorensStowers Institute for Medical Research, Kansas City, MO 64110.ORCID 0000-0002-9310-6650
Audrey P GaschLaboratory of Genetics, University of Wisconsin-Madison, Madison, WI 53706.
Dirk EickDepartment of Molecular Epigenetics, Helmholtz Center Munich, Center for Integrated Protein Science, 81377 Munich, Germany.
Michael P WashburnStowers Institute for Medical Research, Kansas City, MO 64110.
Gabriele VaraniDepartment of Chemistry, University of Washington, Seattle, WA 98195.
Aseem Z AnsariDepartment of Biochemistry, University of Wisconsin-Madison, Madison, WI 53706; azansari@wisc.edu.ORCID 0000-0003-1432-4498
University of Wisconsin–Madison · USStowers Institute for Medical Research · USCenter for Integrated Protein Science Munich · DEUniversity of Washington · US

Funding

GRADUATE TRAINING IN MOLECULAR BIOSCIENCEST32GM007215 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI HULL, CHRISTINA M · 1985 to 2018
$22.5M
Chemistry-Biology Interface Training ProgramT32GM008505 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI BLACKWELL, HELEN E. · 1993 to 2023
$9.8M
Specificity of mRNA 3'-end processing and transcription terminationR01GM064440 · NIGMS · UNIVERSITY OF WASHINGTON · PI VARANI, GABRIELE · 2002 to 2015
$4.5M
Functional Genomics of Stress Defense in YeastR01GM083989 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI GASCH, AUDREY · 2008 to 2016
$3.0M
Deciphering the molecular and physiological cues that guide CTD patterning by Bur1/Cdk9R01GM117362 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI ANSARI, ASEEM Z · 2016 to 2019
$1.3M
NIGMS NIH HHS R01 GM064440NIGMS NIH HHS R01 GM083989NIGMS NIH HHS R01 GM117362NIGMS NIH HHS T32 GM007215NIGMS NIH HHS T32 GM008505
6 · The paper itself

Abstract

The carboxyl-terminal domain (CTD) of the largest subunit of RNA polymerase II (Pol II) orchestrates dynamic recruitment of specific cellular machines during different stages of transcription. Signature phosphorylation patterns of Y

Indexed as

Amino Acid SequencePeptide Termination FactorsPhosphorylationProtein DomainsProtein IsoformsRNA Polymerase IIRNA, Small NucleolarRNA, Small UntranslatedRNA, UntranslatedSaccharomyces cerevisiaeSaccharomyces cerevisiae ProteinsSerineThreonineTranscription FactorsTranscription, GeneticPeptide Termination FactorsProtein IsoformsRNA Polymerase IIRNA, Small NucleolarRNA, Small UntranslatedRNA, UntranslatedRtt103 protein, S cerevisiaeSaccharomyces cerevisiae ProteinsSerineThreonineTranscription FactorsCTD codeCTD interactomeNMRnoncoding RNAphosphothreonine

Identifiers

PMID28465432
PMCPMC5441780
OpenAlexW2610933216

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.