Evidence map›Paper›PMID 28465430›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2017

Molecular codes for cell type specification in Brn3 retinal ganglion cells.

Szilard Sajgo, Miruna Georgiana Ghinia, Matthew Brooks, Friedrich Kretschmer, Katherine Chuang, Suja Hiriyanna, Zhijian Wu, Octavian Popescu, Tudor Constantin Badea

Abstract readValidation Study
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.

0numbers the graph read from it
0cells of the map it votes in
43citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

43 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. InducibleCells · 2023
    Article
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  8. Review
  9. Article
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  18. Article
  19. Review
  20. Genetic control of retinal ganglion cell genesis.Cellular and molecular life sciences : CMLS · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Szilard SajgoRetinal Circuits Development and Genetics Unit, Neurobiology-Neurodegeneration and Repair Laboratory, National Eye Institute, Bethesda, MD 20892.
Miruna Georgiana GhiniaRetinal Circuits Development and Genetics Unit, Neurobiology-Neurodegeneration and Repair Laboratory, National Eye Institute, Bethesda, MD 20892.
Matthew BrooksGenomics Core, Neurobiology-Neurodegeneration and Repair Laboratory, National Eye Institute, Bethesda, MD 20892.
Friedrich KretschmerRetinal Circuits Development and Genetics Unit, Neurobiology-Neurodegeneration and Repair Laboratory, National Eye Institute, Bethesda, MD 20892.
Katherine ChuangRetinal Circuits Development and Genetics Unit, Neurobiology-Neurodegeneration and Repair Laboratory, National Eye Institute, Bethesda, MD 20892.
Suja HiriyannaOcular Gene Therapy Core, National Eye Institute, Bethesda, MD 20892.
Zhijian WuOcular Gene Therapy Core, National Eye Institute, Bethesda, MD 20892.
Octavian PopescuInstitute of Biology, Romanian Academy, Bucharest 060031, Romania.
Tudor Constantin BadeaRetinal Circuits Development and Genetics Unit, Neurobiology-Neurodegeneration and Repair Laboratory, National Eye Institute, Bethesda, MD 20892; badeatc@mail.nih.gov.

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
Retinal Circuit Development & GeneticsZIAEY000504 · NEI · NATIONAL EYE INSTITUTE · PI BADEA, TUDOR · 2011 to 2021
$15.6M
Retinal Gene TherapyZIAEY000443 · NEI · NATIONAL EYE INSTITUTE · PI LI, TIANSEN · 2009 to 2020
$8.4M
NCATS NIH HHS UL1 TR001863
6 · The paper itself

Abstract

Visual information is conveyed from the eye to the brain by distinct types of retinal ganglion cells (RGCs). It is largely unknown how RGCs acquire their defining morphological and physiological features and connect to upstream and downstream synaptic partners. The three Brn3/Pou4f transcription factors (TFs) participate in a combinatorial code for RGC type specification, but their exact molecular roles are still unclear. We use deep sequencing to define (

Indexed as

AnimalsAxon GuidanceBrainCell CommunicationFemaleGene Expression ProfilingHigh-Throughput Nucleotide SequencingMaleMembrane ProteinsMiceRetinal Ganglion CellsTranscription Factor Brn-3TranscriptomeMembrane ProteinsTranscription Factor Brn-3neuronal cell typesPou4f1Pou4f2retinal ganglion cellstranscription factors

Identifiers

PMID28465430
PMCPMC5441800

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.