Evidence map›Paper›PMID 28465425›Full record

ArticlemBio2017

Plasma Membrane Association by N-Acylation Governs PKG Function in

Kevin M Brown, Shaojun Long, L David Sibley

Open access · goldAbstract read
In one paragraph

Article in mBio, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 130 papers.

0numbers the graph read from it
0cells of the map it votes in
130citing papers in PubMed
12.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

130 citing papers in PubMed, 209 citations in OpenAlex.

  1. Article
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  10. Two anchoring proteins control daughter apical complex assembly inbioRxiv : the preprint server for biology · 2026
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  12. Atomic models of the Toxoplasma cell invasion machinery.Nature structural & molecular biology · 2026
    Article
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  15. Article
  16. Article
  17. Specific auxin and medium combinations alterbioRxiv : the preprint server for biology · 2025
    Article
  18. Elucidating the Role ofBiomolecules · 2025
    Article
  19. Article
  20. Article

70 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Kevin M BrownDepartment of Molecular Microbiology, Washington University School of Medicine, St. Louis, Missouri, USA.
Shaojun LongDepartment of Molecular Microbiology, Washington University School of Medicine, St. Louis, Missouri, USA.
L David SibleyDepartment of Molecular Microbiology, Washington University School of Medicine, St. Louis, Missouri, USA sibley@wustl.edu.
Washington University in St. Louis · US

Funding

PROTEIN SECRETION &INTRACELLULAR SURVIVAL BY TOXOPLASMAR01AI034036 · NIAID · WASHINGTON UNIVERSITY · PI SIBLEY, L. DAVID · 1993 to 2019
$7.9M
NIAID NIH HHS R01 AI034036
6 · The paper itself

Abstract

Cyclic GMP (cGMP)-dependent protein kinase (protein kinase G [PKG]) is essential for microneme secretion, motility, invasion, and egress in apicomplexan parasites, However, the separate roles of two isoforms of the kinase that are expressed by some apicomplexans remain uncertain. Despite having identical regulatory and catalytic domains, PKG

Indexed as

AcylationAnimalsCell MembraneCyclic GMPCyclic GMP-Dependent Protein KinasesGene EditingHumansIndoleacetic AcidsPhosphorylationProtein IsoformsProtozoan ProteinsSignal TransductionToxoplasmaToxoplasmosisCyclic GMPCyclic GMP-Dependent Protein KinasesIndoleacetic AcidsProtein IsoformsProtozoan Proteins

Identifiers

PMID28465425
PMCPMC5414004
OpenAlexW2611613282

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.