Strenuous exercise triggers a life-threatening response in mice susceptible to malignant hyperthermia.

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

Who cites it

26 citing papers in PubMed, 37 citations in OpenAlex.

1. Skeletal muscle disorders as risk factors for type 2 diabetes.Molecular and cellular endocrinology · 2025
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2. Targeting mitochondrial CaThe Journal of physiology · 2024
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3. The pathophysiology of rhabdomyolysis in ungulates and rats: towards the development of a rodent model of capture myopathy.Veterinary research communications · 2023
   Review
4. Muscle calcium stress cleaves junctophilin1, unleashing a gene regulatory program predicted to correct glucose dysregulation.eLife · 2023
   Article
5. Mutations in proteins involved in E-C coupling and SOCE and congenital myopathies.The Journal of general physiology · 2022
   Review
6. Oxygen Consumption and Basal Metabolic Rate as Markers of Susceptibility to Malignant Hyperthermia and Heat Stroke.Cells · 2022
   Article
7. Variants in ASPH cause exertional heat illness and are associated with malignant hyperthermia susceptibility.Nature communications · 2022
   Article
8. High-Fat Diet Impairs Muscle Function and Increases the Risk of Environmental Heatstroke in Mice.International journal of molecular sciences · 2022
   Article
9. Endurance exercise attenuates juvenile irradiation-induced skeletal muscle functional decline and mitochondrial stress.Skeletal muscle · 2022
   Article
10. Store-Operated CaInternational journal of molecular sciences · 2022
    Article
11. Classic and exertional heatstroke.Nature reviews. Disease primers · 2022
    Review
12. Ablation of Calsequestrin-1, CaFrontiers in physiology · 2022
    Review
13. Altered CaMetabolites · 2021
    Review
14. Caffeine as a tool to investigate sarcoplasmic reticulum and intracellular calcium dynamics in human skeletal muscles.Journal of muscle research and cell motility · 2021
    Review
15. Calsequestrin, a key protein in striated muscle health and disease.Journal of muscle research and cell motility · 2021
    Review
16. Adaptive thermogenesis enhances the life-threatening response to heat in mice with an Ryr1 mutation.Nature communications · 2020
    Article
17. Pre-assembled Ca2+ entry units and constitutively active Ca2+ entry in skeletal muscle of calsequestrin-1 knockout mice.The Journal of general physiology · 2020
    Article
18. Calsequestrin Deletion Facilitates Hippocampal Synaptic Plasticity and Spatial Learning in Post-Natal Development.International journal of molecular sciences · 2020
    Article
19. Sex-specific alterations in whole body energetics and voluntary activity in heterozygous R163C malignant hyperthermia-susceptible mice.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2020
    Article
20. Preclinical model systems of ryanodine receptor 1-related myopathies and malignant hyperthermia: a comprehensive scoping review of works published 1990-2019.Orphanet journal of rare diseases · 2020
    Article

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

Authors and funding

6 authors at 2 institutions in 1 country.

Funding

Abstract

Indexed as