Evidence map›Paper›PMID 28465306›Full record

ArticleBMJ open2017

High adherence to the 'Wise List' treatment recommendations in Stockholm: a 15-year retrospective review of a multifaceted approach promoting rational use of medicines.

Jaran Eriksen, Lars L Gustafsson, Kristina Ateva, Pia Bastholm-Rahmner, Marie-Louise Ovesjö, Malena Jirlow, Maria Juhasz-Haverinen, Gerd Lärfars, Rickard E Malmström, Björn Wettermark and 2 more

Abstract read
In one paragraph

Article in BMJ open, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers.

0numbers the graph read from it
0cells of the map it votes in
52citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

52 citing papers in PubMed.

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  8. Specific features of rational pharmacotherapy in elderly patients.European journal of hospital pharmacy : science and practice · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Jaran EriksenDivision of Clinical Pharmacology, Department of Laboratory Medicine, Karolinska Institutet, Stockholm, Sweden.ORCID 0000-0003-1146-5615
Lars L GustafssonDivision of Clinical Pharmacology, Department of Laboratory Medicine, Karolinska Institutet, Stockholm, Sweden.
Kristina AtevaStockholm Drug and Therapeutics Committee, Public Healthcare Services Committee, Stockholm, Sweden.
Pia Bastholm-RahmnerMedical Management Centre, Department of Learning, Informatics, Management and Ethics (LIME), Karolinska Institutet, Stockholm, Sweden.
Marie-Louise OvesjöDivision of Clinical Pharmacology, Department of Laboratory Medicine, Karolinska Institutet, Stockholm, Sweden.
Malena JirlowPublic Healthcare Services Committee, Stockholm, Sweden.
Maria Juhasz-HaverinenPublic Healthcare Services Committee, Stockholm, Sweden.
Gerd LärfarsDepartment of Clinical Science and Education, Södersjukhuset, Internal Medicine, Karolinska Institutet, Stockholm, Sweden.
Rickard E MalmströmDivision of Clinical Pharmacology, Department of Laboratory Medicine, Karolinska Institutet, Stockholm, Sweden.
Björn WettermarkDivision of Clinical Pharmacology, Department of Laboratory Medicine, Karolinska Institutet, Stockholm, Sweden.
Eva Andersén-KarlssonDepartment of Clinical Science and Education, Södersjukhuset, Internal Medicine, Karolinska Institutet, Stockholm, Sweden.
Stockholm DTC

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesTo present the 'Wise List' (a formulary of essential medicines for primary and specialised care in Stockholm Healthcare Region) and assess adherence to the recommendations over a 15-year period.

designRetrospective analysis of all prescription data in the Stockholm Healthcare Region between 2000 and 2015 in relation to the Wise List recommendations during the same time period.

settingAll outpatient care in the Stockholm Healthcare Region.

participantsAll prescribers in the Stockholm Healthcare Region.

main outcome measuresThe number of core and complementary substances included in the Wise List, the adherence to recommendations by Anatomic Therapeutic Chemical (ATC) 1st level using defined daily doses (DDDs) adjusted to the DDD for 2015, adherence to recommendations over time measured by dispensed prescriptions yearly between 2002 and 2015.

resultsThe number of recommended core substances was stable (175-212). Overall adherence to the recommendations for core medicines for all prescribers increased from 75% to 84% (2000 to 2015). The adherence to recommendations in primary care for core medicines increased from 80% to 90% (2005 to 2015) with decreasing range in practice variation (32% to 13%). Hospital prescriber adherence to core medicine recommendations was stable but increased for the combination core and complementary medicines from 77% to 88% (2007 to 2015). Adherence varied between the 4 therapeutic areas studied.

conclusionsHigh and increasing adherence to the Wise List recommendations was seen for all prescriber categories. The transparent process for developing recommendations involving respected experts and clinicians using strict criteria for handling potential conflicts of interests, feedback to prescribers, continuous medical education and financial incentives are possible contributing factors. High-quality evidence-based recommendations to prescribers, such as the Wise List, disseminated through a multifaceted approach, will become increasingly important and should be developed further to include recommendations and introduction protocols for new expensive medicines.

Indexed as

Drugs, EssentialAmbulatory CareCost-Benefit AnalysisDrug PrescriptionsDrug UtilizationEvidence-Based PracticeGuideline AdherenceHumansPharmacy and Therapeutics CommitteePractice Guidelines as TopicPractice Patterns, Physicians'Retrospective StudiesSwedenDrugs, EssentialAdherenceDrug and therapeutics committeeEssential medicinesHealth systemsprescribingRational Use of Medicines

Identifiers

PMID28465306
PMCPMC5775463

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.