ArticleBMC complementary and alternative medicine2017
Effect of total flavonoids of Spatholobus suberectus Dunn on PCV2 induced oxidative stress in RAW264.7 cells.
Article in BMC complementary and alternative medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed.
- The roles and mechanisms of natural compounds in preventing and treating viral reproductive disorders in major economic livestock.Virulence · 2026Review
- Flavonoids ofVeterinary sciences · 2025Article
- Normal butanol fraction ofFrontiers in veterinary science · 2025Article
- Self-healing hydrogels loaded with Spatholobi Caulis alleviate disc degeneration by promoting autophagy in nucelus pulposus.Materials today. Bio · 2024Article
- Diversity of fungal community and quality evaluation of Spatholobus Suberectus Dunn during the process of mildew.AMB Express · 2024Article
- Article
- Revisiting Porcine Circovirus Infection: Recent Insights and Its Significance in the Piggery Sector.Vaccines · 2023Review
- Pharmacodynamic Material Basis and Potential Mechanism Study of Spatholobi Caulis in Reversing Osteoporosis.Evidence-based complementary and alternative medicine : eCAM · 2023Article
- A Review of the Pharmacological Potential ofCells · 2022Review
- An ethyl acetate fraction of flavonoids fromVeterinary research forum : an international quarterly journal · 2022Article
- Flavonoids as Potential Antiviral Agents for Porcine Viruses.Pharmaceutics · 2022Review
- Flower extract ofIranian journal of basic medical sciences · 2021Article
- Establishment of inflammatory model induced byJournal of veterinary science · 2021Article
- The Antitriple Negative Breast cancer Efficacy ofOxidative medicine and cellular longevity · 2021Article
- The combined usage of Matrine and Osthole inhibited endoplasmic reticulum apoptosis induced by PCV2.BMC microbiology · 2020Article
- Cepharanthine and Curcumin inhibited mitochondrial apoptosis induced by PCV2.BMC veterinary research · 2020Article
- Oral Administration of Liquiritigenin Confers Protection from Atopic Dermatitis through the Inhibition of T Cell Activation.Biomolecules · 2020Article
- Synthesis of caffeic acid sulfonamide derivatives and their protective effect against HRSC advances · 2020Article
- Anti-Inflammatory Activity of Some Characteristic Constituents from the Vine Stems ofMolecules (Basel, Switzerland) · 2019Article
- Immunomodulatory and antioxidant effects of total flavonoids of Spatholobus suberectus Dunn on PCV2 infected mice.Scientific reports · 2017Article
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThis study was carried out to investigate the effect of total flavonoids of Spatholobus suberectus Dunn (TFSD) on PCV2 induced oxidative stress in RAW264.7 cells.
methodsOxidative stress model was established in RAW264.7 cells by infecting with PCV2. Virus infected cells were then treated with various concentrations (25 mg/ml, 50 mg/ml and 100 mg/ml) of TFSD. The levels of oxidative stress related molecules (NO, ROS, GSH and GSSG) and activities of associated enzymes (SOD, MPO and XOD were analyzed using ultraviolet spectrophotometry, fluorescence method and commercialized detection kits.
resultsPCV2 infection induced significant increase of NO secretion, ROS generation, GSSG content, activities of both XOD and MPO, and dramatically decrease of GSH content and SOD activity in RAW264.7 cells (P < 0.05). After treating with TFSD, PCV2 induced alteration of oxidative stress related molecule levels and enzyme activities were recovered to a level similar to control.
conclusionOur findings indicated that TFSD was able to regulate oxidative stress induced by PCV2 infection in RAW264.7 cells, which supports the ethnomedicinal use of this herb as an alternative or complementary therapeutic drug for reactive oxygen-associated pathologies.
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