ArticleReproductive biology and endocrinology : RB&E2017
Intracerebroventricular injection of RFRP-3 delays puberty onset and stimulates growth hormone secretion in female rats.
Article in Reproductive biology and endocrinology : RB&E, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 40 citations in OpenAlex.
- Chemogenetic Activation of RFRP Neurons Reduces LH Pulse Frequency in Female but not Male Mice.Journal of the Endocrine Society · 2024Article
- Grid1 regulates the onset of puberty in female rats.The Journal of veterinary medical science · 2024Article
- Article
- Effect of nourishing and purging fire Chinese herbal mixture on delaying light-induced premature puberty in rats.Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan · 2024Article
- Sertoli cell-conditioned medium can improve blood-testis-barrier function and spermatogenesis in azoospermia mice induced by scrotal hyperthermia: An experimental study.International journal of reproductive biomedicine · 2024Article
- The Role of RFRP Neurons in the Allostatic Control of Reproductive Function.International journal of molecular sciences · 2023Review
- Effects of RFRP‑3 on an ovariectomized estrogen‑primed rat model and HEC‑1A human endometrial carcinoma cells.Experimental and therapeutic medicine · 2023Article
- Maternal aromatase inhibition via letrozole altered RFamide-related peptide-3 and gonadotropin-releasing hormone expression in pubertal female rats.Iranian journal of basic medical sciences · 2022Article
- RFamide peptides, the novel regulators of mammalian HPG axis: A review.Veterinary world · 2021Review
- RFamide-related peptides' gene expression, polymorphism, and their association with reproductive traits in chickens.Poultry science · 2021Article
- RF-amide related peptide-3 (RFRP-3): a novel neuroendocrine regulator of energy homeostasis, metabolism, and reproduction.Molecular biology reports · 2021Review
- Rfamide-related peptide-3 suppresses the substance P-induced promotion of the reproductive performance in female rats modulating hypothalamic Kisspeptin expression.Experimental brain research · 2020Article
- Effect of GABA-T on Reproductive Function in Female Rats.Animals : an open access journal from MDPI · 2020Article
- Reproductive neuroendocrinology of mammalian gonadotropin-inhibitory hormone.Reproductive medicine and biology · 2019Review
- The roles of RFamide-related peptides (RFRPs), mammalian gonadotropin-inhibitory hormone (GnIH) orthologues in female reproduction.Iranian journal of basic medical sciences · 2018Review
- Sex- and brain region-specific patterns of gene expression associated with socially-mediated puberty in a eusocial mammal.PloS one · 2018Article
- Precocious Puberty and the Lin28/Let7 Pathway: The Therapeutic Effect of the Nourishing "Yin" and Purging "Fire" Traditional Chinese Medicine Mixture in a Rat Model.Evidence-based complementary and alternative medicine : eCAM · 2018Article
- Is precocious puberty linked to hypothalamic expression of arginine-phenylalanine-amide-related peptide?Iranian journal of basic medical sciences · 2017Review
- Expression and co-localization of RFRP-3 and kisspeptin during breeding and non-breeding season in the hypothalamus of male rhesus monkey (Reproductive medicine and biologyArticle
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPuberty onset is a complex, organized biological process with multilevel regulation, and its physiopathological mechanisms are yet to be elucidated. RFRP-3, the mammalian ortholog to gonadotropin-inhibitory hormone, is implicated in inhibiting the synthesis and release of gonadotropin in mammals. However, it is unclear whether RFRP-3 participates in regulating pubertal development.
methodsThis study investigated the functional significance and regulatory mechanism of hypothalamic RFRP-3 neuropeptide in the onset of puberty in young female rats. On postnatal day 22, we implanted cannulas into the lateral ventricles of female rat pups. From postnatal day 28 to postnatal day 36, the intracerebroventricular injection of RFRP-3, or vehicle, was conducted twice a day. To investigate whether puberty onset was affected, we examined the body weight, age of vaginal opening, serum hormone levels, uterus and ovary development, and hypothalamic Kiss-1 mRNA expression.
resultsIntracerebroventricular injection of RFRP-3 significantly decreased the serum concentrations of luteinizing hormone and estradiol, delayed uterine maturation, and postponed the time of vaginal opening. This study suggests that RFRP-3 can delay the onset of puberty in young female rats; the expression of Kiss-1 mRNA is potently inhibited in the RFRP-3 group. Moreover, our data show that RFRP-3 elevates serum growth hormone levels.
conclusionsThese data suggest that intracerebroventricular injection of RFRP-3 significantly delays the onset of puberty in female rats. Additionally, RFRP-3 may be associated with prepubertal rise in the secretion of growth hormone.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.