ArticleBMC cancer2017
Diagnostic value of endoscopic appearance during ductoscopy in patients with pathological nipple discharge.
Article in BMC cancer, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.
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Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Meta-analysis and cost-effectiveness of ductoscopy, duct excision surgery and MRI for the diagnosis and treatment of patients with pathological nipple discharge.Breast cancer research and treatment · 2021Pooled it
- Clinical and Imaging Characteristics in the Diagnosis and Surgical Management of Nipple Discharge Without Clinically Palpable Masses: A Retrospective Cohort Study.Thoracic cancer · 2026Article
- Role of immediate injection of methylene blue after fiberoptic ductoscopy in selective ductectomy for patients with pathological nipple discharge.BMC cancer · 2025Article
- Deep learning for real-time detection of breast cancer presenting pathological nipple discharge by ductoscopy.Frontiers in oncology · 2023Article
- A comparative analysis of diagnostic values of high-frequency ultrasound and fiberoptic ductoscopy for pathologic nipple discharge.BMC medical imaging · 2022Article
- Diagnostic value of sialyl-Tn immunocytochemistry in breast cancer presenting with pathological nipple discharge.Cancer medicine · 2021Article
- Patient-reported outcomes of ductoscopy procedures for pathologic nipple discharge.Breast cancer (Tokyo, Japan) · 2021Article
- Detection of breast cancer precursor lesions by autofluorescence ductoscopy.Breast cancer (Tokyo, Japan) · 2021Observational
- Risk factors of breast intraductal lesions in patients without pathological nipple discharge.Molecular and clinical oncology · 2020Article
- Low-dose CT combined mammography in diagnosis of overflow breast disease: A protocol of systematic review.Medicine · 2020Article
- Evaluation and management of pathological nipple discharges without using intraductal imaging methods.Irish journal of medical science · 2020Article
- An Improved Nomogram to Reduce False-Positive Biopsy Rates of Breast Imaging Reporting and Data System Ultrasonography Category 4A Lesions.Cancer control : journal of the Moffitt Cancer CenterArticle
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6 authors.
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Abstract
backgroundTo explore the features of ductoscopic appearance that may be diagnostic in patients with pathologic nipple discharge (PND) and to discuss the diagnostic criteria for intraductal tumors.
methodsWe reviewed 247 patients with PND but without a palpable mass who were evaluated using either surgical biopsy or excision. Data concerning patient age, duration of discharge, discharge color, and the details of endoscopic appearance were analyzed according to the pathological results.
resultsThe postoperative diagnosis in 61 patients (24.70%) was a nonmass lesion, and 186 patients (76.52%) had an intraductal tumor. Among those with intraductal lesions, 10 patients (4.05%) had a malignant tumor, including 4 (1.62%) with ductal carcinoma in situ and 6 (2.43%) with invasive ductal carcinoma. On univariate analysis, patients of older age with spontaneous and bloody discharge were more likely to suffer from intraductal lesions. On logistic regression analysis, bloody nipple discharge, morphology, and a broad lesion base revealed by ductoscopy showed a statistically significant correlation with malignancy (p = 0.001, p < 0.001, p = 0.022, respectively).
conclusionsBoth clinical features and endoscopic appearance are significant for the precise diagnosis of an intraductal lesion seen on ductoscopy. The endoscopic features of bloody discharge, morphology, and a broad lesion base are independent risk factors for malignancy and represent new criteria for the diagnosis of patients with PND.
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