Trial reportThe journal of spinal cord medicine2018
Oral probenecid improves sperm motility in men with spinal cord injury.
Trial report in The journal of spinal cord medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05903859 (Improvement of Reproductive Function in Men With Spinal Cord Injury), which is not on this map. Cited by 10 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Improvement of Reproductive Function in Men With Spinal Cord Injury (SCI)
Who cites it
10 citing papers in PubMed, 20 citations in OpenAlex.
- Spinal cord injury and male infertility: Effect of the inflammasome proteins on semen quality.The journal of spinal cord medicine · 2025Article
- Comparative study of the effects of baicalin and probenecid on microRNA expression profiles in porcine aortic vascular endothelial cells infected by Glaesserella parasuis.BMC veterinary research · 2025Article
- The time course of nod-like receptor family pyrin domain containing 3 inflammasome complex expressions in the testis tissue of an experimental varicocele rat model: An experimental study.International journal of reproductive biomedicine · 2023Article
- Effects of autonomic nervous system disorders on male infertility.Frontiers in neurology · 2023Review
- Sexuality, Intimacy, and Reproductive Health after Spinal Cord Injury.Journal of personalized medicine · 2022Review
- The NLRP3 inflammasome: molecular activation and regulation in spermatogenesis and male infertility; a systematic review.Basic and clinical andrology · 2022Review
- Proteomic insight of seminal plasma in spinal cord injured men submitted to oral probenecid treatment for improved motility.The journal of spinal cord medicine · 2021Article
- Spinal cord injury and male infertility-a review of current literature, knowledge gaps, and future research.Translational andrology and urology · 2018Review
- Informing the knowledge economy: Options for extending the reach of research.The journal of spinal cord medicine · 2018Article
- Understanding the seminal plasma proteome and its role in male fertility.Basic and clinical andrology · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
STUDY
designProspective cohort study (twenty men with spinal cord injury [SCI]).
objectiveDetermine if administration of oral probenecid results in improved sperm motility in men with SCI.
settingMajor university medical center.
methodsTwenty men with SCI were administered probenecid for 4 weeks (250 mg twice a day for 1 week, followed by 500 mg twice a day for 3 weeks). Semen quality was assessed at three time points: pre-treatment, post-treatment (immediately after the 4-week treatment), and follow-up (4 weeks after the last pill was ingested). RESULT(S): Probenecid was well-tolerated by all subjects. Sperm motility improved in each subject after 4 weeks of oral probenecid. The mean percent of sperm with progressive motility increased from 19% to 26% (P < 0.05). A more striking increase was seen in the mean percent of sperm with rapid linear motility, from 5% to 17%, (P <0.001). This improvement continued into the four week follow up period. Similar improvements were seen in the total motile sperm count (15 million, 28 million, and 27 million at pre-treatment, post-treatment, and follow-up, respectively). Sperm concentration was not significantly different at pre-treatment, post-treatment, and follow-up, (52 million, 53 million and 53 million, respectively).
conclusionThis study showed that administration of an oral agent (probenecid) known to interfere with the pannexin-1 cellular membrane channel, can improve sperm motility in men with spinal cord injury. It is the first study to report improved sperm motility after oral medication in men with SCI.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.