ArticleStatistics in medicine2017
The use of permutation tests for the analysis of parallel and stepped-wedge cluster-randomized trials.
Article in Statistics in medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed.
- Opportunistic Treatment of Hepatitis C Infection Among Hospitalized People Who Inject Drugs (OPPORTUNI-C): A Stepped Wedge Cluster Randomized Trial.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2024Trial
- Mobile health school screening and telemedicine referral to improve access to specialty care in rural Alaska: a cluster- randomised controlled trial.The Lancet. Global health · 2022Trial
- Considerations Before Selecting a Stepped-Wedge Cluster Randomized Trial Design for a Practice Improvement Study.Annals of family medicineTrial
- Permutation tests for detecting treatment effect heterogeneity in cluster randomized trials.Statistical methods in medical research · 2025Article
- A review of current practice in the design and analysis of extremely small stepped-wedge cluster randomized trials.Clinical trials (London, England) · 2025Review
- Maintaining the validity of inference from linear mixed models in stepped-wedge cluster randomized trials under misspecified random-effects structures.Statistical methods in medical research · 2024Article
- Robust analysis of stepped wedge trials using composite likelihood models.Statistics in medicine · 2024Article
- Permutation-based multiple testing corrections forStatistics in medicine · 2023Article
- A platform trial design for preventive vaccines against Marburg virus and other emerging infectious disease threats.Clinical trials (London, England) · 2022Article
- Design and analysis of cluster randomized trials with time-to-event outcomes under the additive hazards mixed model.Statistics in medicine · 2022Article
- Network methods and design of randomized trials: Application to investigation of COVID-19 vaccination boosters.Clinical trials (London, England) · 2022Article
- A comparison of analytical strategies for cluster randomized trials with survival outcomes in the presence of competing risks.Statistical methods in medical research · 2022Article
- Stepped Wedge Cluster Randomized Trials: A Methodological Overview.World neurosurgery · 2022Review
- Randomization-based confidence intervals for cluster randomized trials.Biostatistics (Oxford, England) · 2021Article
- Randomization-based inference for a marginal treatment effect in stepped wedge cluster randomized trials.Statistics in medicine · 2021Article
- Estimation of conditional power for cluster-randomized trials with interval-censored endpoints.Biometrics · 2021Article
- Accounting for confounding by time, early intervention adoption, and time-varying effect modification in the design and analysis of stepped-wedge designs: application to a proposed study design to reduce opioid-related mortality.BMC medical research methodology · 2021Article
- Mixed-effects models for the design and analysis of stepped wedge cluster randomized trials: An overview.Statistical methods in medical research · 2021Review
- Using the potential outcome framework to estimate optimal sample size for cluster randomized trials: a simulation-based algorithm.Journal of statistical computation and simulation · 2021Article
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2 authors.
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Abstract
We investigate the use of permutation tests for the analysis of parallel and stepped-wedge cluster-randomized trials. Permutation tests for parallel designs with exponential family endpoints have been extensively studied. The optimal permutation tests developed for exponential family alternatives require information on intraclass correlation, a quantity not yet defined for time-to-event endpoints. Therefore, it is unclear how efficient permutation tests can be constructed for cluster-randomized trials with such endpoints. We consider a class of test statistics formed by a weighted average of pair-specific treatment effect estimates and offer practical guidance on the choice of weights to improve efficiency. We apply the permutation tests to a cluster-randomized trial evaluating the effect of an intervention to reduce the incidence of hospital-acquired infection. In some settings, outcomes from different clusters may be correlated, and we evaluate the validity and efficiency of permutation test in such settings. Lastly, we propose a permutation test for stepped-wedge designs and compare its performance with mixed-effect modeling and illustrate its superiority when sample sizes are small, the underlying distribution is skewed, or there is correlation across clusters. Copyright © 2017 John Wiley & Sons, Ltd.
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