Evidence map›Paper›PMID 28464501›Full record

ArticleJournal of biophotonics2017

Sensitivity of spatially offset Raman spectroscopy (SORS) to subcortical bone tissue.

Guanping Feng, Marien Ochoa, Jason R Maher, Hani A Awad, Andrew J Berger

Abstract readLetter
In one paragraph

Article in Journal of biophotonics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed.

  1. Article
  2. Raman Microscopy and Bone.Methods in molecular biology (Clifton, N.J.) · 2025
    Article
  3. Article
  4. Bone health: Quality versus quantity.Journal of the Pediatric Orthopaedic Society of North America · 2024
    Article
  5. Assessment of spatially offset Raman spectroscopy to detect differences in bone matrix quality.Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy · 2023
    Article
  6. Article
  7. Review
  8. Article
  9. Review
  10. Review
  11. Article
  12. Review
  13. Non-invasiveTheranostics · 2019
    Article
  14. Spatially offset Raman spectroscopy forBiomedical optics express · 2018
    Article
  15. Article
  16. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Guanping FengThe Institute of Optics, University of Rochester, 275 Hutchinson Road, Rochester, New York, 14627.
Marien OchoaThe Institute of Optics, University of Rochester, 275 Hutchinson Road, Rochester, New York, 14627.
Jason R MaherThe Institute of Optics, University of Rochester, 275 Hutchinson Road, Rochester, New York, 14627.
Hani A AwadDepartment of Biomedical Engineering, University of Rochester, 207 Robert B. Goergen Hall, Rochester, New York, 14627.
Andrew J BergerThe Institute of Optics, University of Rochester, 275 Hutchinson Road, Rochester, New York, 14627.

Funding

Raman spectroscopic platform for transcutaneous monitoring of bone qualityR01AR070613 · NIAMS · UNIVERSITY OF ROCHESTER · PI Hani A Awad, ANDREW J BERGER · 2016 to 2026
$4.0M
Noninvasive optical monitoring of bone quality in an arthritic mouse modelR21AR061285 · NIAMS · UNIVERSITY OF ROCHESTER · PI AWAD, HANI A, BERGER, ANDREW J · 2011 to 2012
$341k
NIAMS NIH HHS R01 AR070613NIAMS NIH HHS R21 AR061285
6 · The paper itself

Abstract

The development of spatially offset Raman spectroscopy (SORS) has enabled deep, non-invasive chemical characterization of turbid media. Here, we use SORS to measure subcortical bone tissue and depth-resolved biochemical variability in intact, exposed murine bones. We also apply the technique to study a mouse model of the genetic bone disorder osteogenesis imperfecta. The results suggest that SORS is more sensitive to disease-related biochemical differences in subcortical trabecular bone and marrow than conventional Raman measurements.

Indexed as

Spectrum Analysis, RamanAnimalsBone and BonesFemaleMaleMiceMice, Inbred C57BLOsteogenesis ImperfectaRabbitsboneosteogenesis imperfectaspatially offset Raman spectroscopy

Identifiers

PMID28464501
PMCPMC5971662

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.