Observational studyCancer medicine2017
Correlation of mammographic density and serum calcium levels in patients with primary breast cancer.
Observational study in Cancer medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 14 citations in OpenAlex.
- Plasma vitamin D binding protein as the potential predictor of depressive disorder risk in breast cancer patients.Scientific reports · 2025Article
- Correlation of RANK and RANKL with mammographic density in primary breast cancer patients.Archives of gynecology and obstetrics · 2024Article
- Update Breast Cancer 2020 Part 3 - Early Breast Cancer.Geburtshilfe und Frauenheilkunde · 2020Article
- Strontium and antimony serum levels in healthy individuals living in high- and low-risk areas of esophageal cancer.Journal of clinical laboratory analysis · 2020Article
- The associations between serum vitamin D, calcium and uterine fibroids in Chinese women: a case-controlled study.The Journal of international medical research · 2020Article
- RANKL and OPG and their influence on breast volume changes during pregnancy in healthy women.Scientific reports · 2020Observational
- Increased Serum Calcium Level Promotes the Risk of Lymph Node Metastasis in Endometrial Cancer.Cancer management and research · 2020Article
- An elevated preoperative serum calcium level is a significant predictor for positive peritoneal cytology in endometrial carcinoma.Chinese journal of cancer research = Chung-kuo yen cheng yen chiu · 2019Article
- Article
- Milk intake and mammographic density in premenopausal women.Breast cancer research and treatment · 2019Article
- Adjuvant Therapy and Mammographic Density Changes in Women With Breast Cancer.JNCI cancer spectrum · 2018Article
- Real-time scratch assay reveals mechanisms of early calcium signaling in breast cancer cells in response to wounding.Oncotarget · 2018Article
- Association of calcium sensing receptor polymorphisms at rs1801725 with circulating calcium in breast cancer patients.BMC cancer · 2017Article
- Correlation of mammographic density and serum calcium levels in patients with primary breast cancer.Cancer medicine · 2017Observational
Corrections and comments
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Authors and funding
14 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Percentage mammographic breast density (PMD) is one of the most important risk factors for breast cancer (BC). Calcium, vitamin D, bisphosphonates, and denosumab have been considered and partly confirmed as factors potentially influencing the risk of BC. This retrospective observational study investigated the association between serum calcium level and PMD. A total of 982 BC patients identified in the research database at the University Breast Center for Franconia with unilateral BC, calcium and albumin values, and mammogram at the time of first diagnosis were included. PMD was assessed, using a semiautomated method by two readers. Linear regression analyses were conducted to investigate the impact on PMD of the parameters of serum calcium level adjusted for albumin level, and well-known clinical predictors such as age, body mass index (BMI), menopausal status and confounder for serum calcium like season in which the BC was diagnosed. Increased calcium levels were associated with reduced PMD (P = 0.024). Furthermore, PMD was inversely associated with BMI (P < 0.001) and age (P < 0.001). There was also an association between PMD and menopausal status (P < 0.001). The goodness-of-fit of the regression model was moderate. This is the first study assessing the association between serum calcium level and PMD. An inverse association with adjusted serum calcium levels was observed. These findings add to previously published data relating to vitamin D, bisphosphonates, denosumab, and the RANK/RANKL signaling pathway in breast cancer risk and prevention.
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