ArticleJournal of biophotonics2017
Optical assessment of changes in mechanical and chemical properties of adipose tissue in diet-induced obese rats.
Article in Journal of biophotonics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 27 citations in OpenAlex.
- Raman analysis of breast cancer-associated adipocytes: A chemometric pipeline for lipid biochemistry profiling.Journal of lipid research · 2026Article
- Quantitative Mapping of Fibrotic Tissue Mechanics via Brillouin Spectroscopy.Journal of biophotonics · 2026Article
- Improvement of gain and spatial resolution for impulsive stimulated Brillouin scattering microscopy.Photoacoustics · 2025Article
- Article
- Light distribution in fat cell layers at physiological temperatures.Scientific reports · 2023Article
- Brillouin Spectroscopy: From Biomedical Research to New Generation Pathology Diagnosis.International journal of molecular sciences · 2021Review
- Mapping mechanical properties of biological materials via an add-on Brillouin module to confocal microscopes.Nature protocols · 2021Article
- Brillouin Light Scattering: Applications in Biomedical Sciences.Chemical reviews · 2019Review
- Differentiating melanoma and healthy tissues based on elasticity-specific Brillouin microspectroscopy.Biomedical optics express · 2019Article
- Nonlinear Brillouin spectroscopy: what makes it a better tool for biological viscoelastic measurements.Biomedical optics express · 2019Article
- Prolonged intake of desloratadine: mesenteric lymphatic vessel dysfunction and development of obesity/metabolic syndrome.American journal of physiology. Gastrointestinal and liver physiology · 2019Article
- Multi-wavelength excitation Brillouin spectroscopy.IEEE journal of selected topics in quantum electronics : a publication of the IEEE Lasers and Electro-optics SocietyArticle
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
Obesity is becoming a leading cause of health problems world-wide. Obesity and overweight are associated with the structural and chemical changes in tissues; however, few methods exist that allow for concurrent measurement of these changes. Using Brillouin and Raman microspectroscopy, both the mechanical and chemical differences can be assessed simultaneously. We hypothesized that Brillouin spectroscopy can measure the adipose tissues' stiffness, which increases in obesity. Samples of brown and white adipose tissues obtained from control and diet-induced obese adult rats were analyzed. The results show that both adipose tissues of the obese group exhibit a greater high-frequency longitudinal elastic modulus than the control samples, and that the brown fat is generally stiffer than white adipose. The Raman spectra indicate that the lipids' accumulation in adipose tissue outpaces the fibrosis, and that the high-fat diet has a greater effect on the brown adipose than the white fat. Overall, the powerful combination of Brillouin and Raman microspectroscopies successfully assessed both the mechanical properties and chemical composition of adipose tissue simultaneously for the first time. The results indicate that the adipose tissue experiences an obesity-induced increase in stiffness and lipid content, with the brown adipose tissue undergoing a more pronounced change compared to white adipose.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.