ArticleClinical cardiology2017
Sustained apnea induces endothelial activation.
Article in Clinical cardiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 20 citations in OpenAlex.
- Interactions with and activation of immune cells by CD41aFrontiers in immunology · 2025Article
- Oxy-Inflammation in Humans during Underwater Activities.International journal of molecular sciences · 2024Review
- Immune interactions and regulation with CD39Frontiers in immunology · 2024Article
- Major Adverse Cardiac and Cerebrovascular Events in Geriatric Patients with Obstructive Sleep Apnea: An Inpatient Sample Analysis.Medical sciences (Basel, Switzerland) · 2023Article
- Circulating miR-206 and miR-1246 as Markers in the Early Diagnosis of Lung Cancer in Patients with Chronic Obstructive Pulmonary Disease.International journal of molecular sciences · 2023Article
- Effect of dry dynamic apnea on aerobic power in elite rugby athletes: a warm-up method.Frontiers in physiology · 2023Article
- Effect of Hypoxia-Induced Micro-RNAs Expression on Oncogenesis.International journal of molecular sciences · 2022Article
- Editorial: Physiology and Physiopathology of Breath-Holding Activity.Frontiers in physiology · 2022Article
- Hematologic changes after short term hypoxia in non-elite apnea divers under voluntary dry apnea conditions.PloS one · 2020Observational
- MicroRNA expression profile during different conditions of hypoxia.Oncotarget · 2018Article
- Endothelial microvesicles in hypoxic hypoxia diseases.Journal of cellular and molecular medicine · 2018Review
- Sleep study-guided multidisciplinary therapy (SGMT) for patients with acute coronary syndrome: Trial rationale and design.Clinical cardiology · 2018Article
- Sustained apnea induces endothelial activation.Clinical cardiology · 2017Article
- Plasma Exosomes and Improvements in Endothelial Function by Angiotensin 2 Type 1 Receptor or Cyclooxygenase 2 Blockade following Intermittent Hypoxia.Frontiers in neurology · 2017Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundApnea diving has gained worldwide popularity, even though the pathophysiological consequences of this challenging sport on the human body are poorly investigated and understood. This study aims to assess the influence of sustained apnea in healthy volunteers on circulating microparticles (MPs) and microRNAs (miRs), which are established biomarkers reflecting vascular function. HYPOTHESIS: Short intermittent hypoxia due to voluntary breath-holding affects circulating levels of endothelial cell-derived MPs (EMPs) and endothelial cell-derived miRs.
methodsUnder dry laboratory conditions, 10 trained apneic divers performed maximal breath-hold. Venous blood samples were taken, once before and at 4 defined points in time after apnea. Samples were analyzed for circulating EMPs and endothelial miRs.
resultsAverage apnea time was 329 seconds (±103), and SpO
conclusionsEven a single maximal breath-hold induces acute endothelial activation and should be performed with great caution by subjects with preexisting vascular diseases. Voluntary apnea might be used as a model to simulate changes in endothelial function caused by hypoxia in humans.
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Registered trials
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