ArticlePloS one2017
Increased anxiety-like behavior is associated with the metabolic syndrome in non-stressed rats.
Article in PloS one, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 65 citations in OpenAlex.
- Impact of a novel ultra-processed foods and drinks diet on metabolism and behaviour in adolescent female and male rats.Scientific reports · 2025Article
- The Influence of Sociodemographic Characteristics, Lifestyle, and Metabolic Syndrome on Anxiety and Depression Symptoms in Adults in Banja Luka.Acta medica academica · 2025Article
- Manganese-induced damage to the serotoninergic system is associated with the development of anxiety and depression.Toxicology reports · 2025Article
- Neurological and metabolic related pathophysiologies and treatment of comorbid diabetes with depression.CNS neuroscience & therapeutics · 2024Review
- Chronic Variable Stress and Cafeteria Diet Combination Exacerbate Microglia andInternational journal of molecular sciences · 2024Article
- Hypoglycemia and anxiolysis mediated by levofloxacin treatment in diabetic rats.Journal of diabetes and metabolic disorders · 2023Article
- Unveiling the Link: Exploring Mitochondrial Dysfunction as a Probable Mechanism of Hepatic Damage in Post-Traumatic Stress Syndrome.International journal of molecular sciences · 2023Article
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- Stress-induced body weight loss and improvements in cardiometabolic risk factors do not translate to improved myocardial ischemic tolerance in western diet-fed mice.Physiological reports · 2022Article
- Effects of Gestational Diabetes in Cognitive Behavior, Oxidative Stress and Metabolism on the Second-Generation Off-Spring of Rats.Nutrients · 2021Article
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- Therapeutic Potential of β-Caryophyllene: A Dietary Cannabinoid in Diabetes and Associated Complications.Nutrients · 2020Review
- Region-specific brain area reductions and increased cholecystokinin positive neurons in diabetic OLETF rats: implication for anxiety-like behavior.The journal of physiological sciences : JPS · 2020Article
- Obesity and Age-Related Changes in the Brain of the ZuckerNutrients · 2020Article
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- Biobehavioral utility of mindfulness-based art therapy: Neurobiological underpinnings and mental health impacts.Experimental biology and medicine (Maywood, N.J.) · 2020Review
- Behavioral Abnormalities in Knockout and Humanized Tau Mice.Frontiers in endocrinology · 2020Article
- Association of serum ferritin level and depression with respect to the body mass index in Korean male adults.Nutrition research and practice · 2019Article
Corrections and comments
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Authors and funding
10 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Metabolic syndrome (MS) is a cluster of signs that increases the risk to develop diabetes mellitus type 2 and cardiovascular disease. In the last years, a growing interest to study the relationship between MS and psychiatric disorders, such as depression and anxiety, has emerged obtaining conflicting results. Diet-induced MS rat models have only examined the effects of high-fat or mixed cafeteria diets to a limited extent. We explored whether an anxiety-like behavior was associated with MS in non-stressed rats chronically submitted to a high-sucrose diet (20% sucrose in drinking water) using three different anxiety paradigms: the shock-probe/burying test (SPBT), the elevated plus-maze (EPM) and the open-field test (OFT). Behaviorally, the high-sucrose diet group showed an increase in burying behavior in the SPBT. Also, these animals displayed both avoidance to explore the central part of the arena and a significant increase in freezing behavior in the OFT and lack of effects in the EPM. Also, high-sucrose diet group showed signs of an MS-like condition: significant increases in body weight and body mass index, abdominal obesity, hypertension, hyperglycemia, hyperinsulinemia, and dyslipidemia. Plasma leptin and resistin levels were also increased. No changes in plasma corticosterone levels were found. These results indicate that rats under a 24-weeks high-sucrose diet develop an MS associated with an anxiety-like behavior. Although the mechanisms underlying this behavioral outcome remain to be investigated, the role of leptin is emphasized.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.