ArticleJournal of critical care2017
Propafenone for supraventricular arrhythmias in septic shock-Comparison to amiodarone and metoprolol.
Article in Journal of critical care, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it, 47 citations in OpenAlex.
- Managing new-onset atrial fibrillation in critically ill patients: a systematic narrative review.BMJ open · 2020Pooled it
- Propafenone versus amiodarone for supraventricular arrhythmias in septic shock: a randomised controlled trial.Intensive care medicine · 2023Trial
- Definitions and outcomes reported in studies investigating the management of new onset atrial fibrillation in acutely unwell patients admitted to the intensive care unit: a scoping review.European heart journal open · 2026Review
- Impact of heart rate on Doppler echocardiography predictors of rhythm control in patients with septic shock.Scientific reports · 2026Article
- Treatment of supraventricular arrhythmias in critical care patients with sepsis.Frontiers in cardiovascular medicine · 2026Review
- Propafenone is associated with fewer recurrences of supraventricular arrhythmias in mechanically ventilated patients with septic shock and right ventricular dysfunction.Frontiers in cardiovascular medicine · 2026Article
- Echocardiography guided management of atrial fibrillation.Intensive care medicine · 2025Review
- Association between heart rate fluctuation and mortality in intensive care patients with atrial fibrillation.Scientific reports · 2025Article
- Landiolol bolus application for tachycardic dysrhythmia in the prehospital EMS setting - An observational study of a novel concept.Scandinavian journal of trauma, resuscitation and emergency medicine · 2025Observational
- Comparison of rhythm and rate control medications for new-onset atrial fibrillation in septic patients: MIMIC-IV database analysis.Journal of translational medicine · 2025Article
- Article
- Evaluation of Amiodarone Administration in Patients with New-Onset Atrial Fibrillation in Septic Shock.Medicina (Kaunas, Lithuania) · 2024Review
- Management of cardiogenic shock: a narrative review.Annals of intensive care · 2024Review
- Management of supraventricular arrhythmias in the intensive care unit: a step in the right direction.Intensive care medicine · 2023Article
- The role of beta-blocker drugs in critically ill patients: a SIAARTI expert consensus statement.Journal of anesthesia, analgesia and critical care · 2023Article
- Recognition and management of hemorrhaging in combination with emerging enterogenic sepsis during a hepatectomy: a case report.BMC anesthesiology · 2023Article
- Treatment strategies for new onset atrial fibrillation in patients treated on an intensive care unit: a systematic scoping review.Critical care (London, England) · 2021Article
- Prognostic impact of sustained new-onset atrial fibrillation in critically ill patients.Intensive care medicine · 2020Article
- Article
- [Atrial fibrillation in patients with sepsis and non-cardiac infections].Herzschrittmachertherapie & Elektrophysiologie · 2019Review
Corrections and comments
- Commented on byReply.2018
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeThe occurence of supraventricular arrhythmias associate with an unfavourable prognosis in septic shock. Propafenone could be a feasible antiarrhythmic. MATERIALS AND
methodsPatients collected over a period of 24months were divided into the three groups based on antiarrhythmic: Group1(amiodarone), Group2(propafenone), Group3(metoprolol). Type of arrhythmia, cardioversion rates, demographic, haemodynamic, laboratory parameters were recorded in the first 24h. The outcome data were compared between the groups.
results234 patients (99.1% ventilated) were included, the prevailing arrhythmia was acute onset atrial fibrillation (AF,69.7%). Except for the dosage of noradrenaline (0.35(0.14-0.78) in Group1(n=142)vs 0.25(0.10-0.50),p<0.01 in Group2(n=78)vs 0.14(0.07-0.25)μg/kg·min,p<0.05 in Group3(n=14)) the ejection fraction of left ventricle, rates of renal replacement therapy, arterial lactate and procalcitonin levels were not different between the groups. The cardioversion rate in Group1(74%) was lower than in Group2(89%) and Group3(92%). ICU and 28-day mortalities of Group1 were not significantly higher than in Group2 and Group3. Multivariate analysis demonstrated higher 12-month mortality in Group1 than in Group2 (HR1.58(1.04;2.38),p=0.03).
conclusionsPropafenone demonstrated a higher cardioversion rate than amiodarone with a similar impact on the outcome. Patients remaining in acute onset arrhythmia did not demonstrate significantly higher ICU, 28-day and 12-month mortalities compared to those successfully cardioverted or to those having chronic AF.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.