Evidence map›Paper›PMID 28463686›Full record

ArticlePhytochemistry2017

Anti-proliferative ambuic acid derivatives from Hawaiian endophytic fungus Pestalotiopsis sp. FT172.

Chun-Shun Li, Bao-Jun Yang, James Turkson, Shugeng Cao

Open access · greenAbstract read
In one paragraph

Article in Phytochemistry, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
4.0field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 36 citations in OpenAlex.

  1. Article
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  4. Molecules (Basel, Switzerland) · 2022
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 1 country.

Chun-Shun LiDepartment of Pharmaceutical Sciences, Daniel K. Inouye College of Pharmacy, University of Hawai'i at Hilo, 200 West Kawili Street, Hilo, HI 96720, USA; Natural Products and Experimental Therapeutics, University of Hawai'i Cancer Center, 701 Ilalo Street, Honolulu, HI 96813, USA.
Bao-Jun YangNatural Products and Experimental Therapeutics, University of Hawai'i Cancer Center, 701 Ilalo Street, Honolulu, HI 96813, USA.
James TurksonNatural Products and Experimental Therapeutics, University of Hawai'i Cancer Center, 701 Ilalo Street, Honolulu, HI 96813, USA.
Shugeng CaoDepartment of Pharmaceutical Sciences, Daniel K. Inouye College of Pharmacy, University of Hawai'i at Hilo, 200 West Kawili Street, Hilo, HI 96720, USA; Natural Products and Experimental Therapeutics, University of Hawai'i Cancer Center, 701 Ilalo Street, Honolulu, HI 96813, USA. Electronic address: scao@hawaii.edu.
University of Hawaii System · USUniversity of Hawaiʻi at Mānoa · USUniversity of Hawaii at Hilo · US

Funding

STAT3, G6PD and TrxR as underlying mechanisms for antitumor responses tohirsutinolidesR01CA208851 · NCI · UNIVERSITY OF HAWAII AT MANOA · PI TURKSON, JAMES K · 2017 to 2021
$2.9M
Salicylic acid-based small-molecule Stat3 inhibitors for anticancer therapyR01CA161931 · NCI · UNIVERSITY OF HAWAII AT MANOA · PI TURKSON, JAMES K · 2012 to 2016
$2.4M
Therapeutic Application of Novel Stat3 Inhibitors in Breast and Pancreatic CancerR01CA128865 · NCI · UNIVERSITY OF HAWAII AT MANOA · PI TURKSON, JAMES K · 2008 to 2011
$805k
NCI NIH HHS R01 CA128865NCI NIH HHS R01 CA161931NCI NIH HHS R01 CA208851
6 · The paper itself

Abstract

Five previously undescribed ambuic acid derivatives, pestallic acids A-E and three known analogs were isolated from the cultured broth of Pestalotiopsis sp. FT172. The structures of the pestallic acids A-E were determined through the analysis of HRMS and NMR spectroscopic data. The absolute configurations (ACs) of pestallic acids B-E were assigned by comparison of the experimental electric circular dichroism (ECD) spectra or the optical rotations with those in the literature. All compounds were tested against A2780 and cisplatin resistant A2780 (A2780CisR) cell lines. Pestallic acid E and (+)-ambuic acid showed potent activities with IC

Indexed as

Antineoplastic Agents, PhytogenicCell Line, TumorCyclohexanonesEndophytesHawaiiHumansMolecular StructurePrimulaceaeXylarialesambuic acidAntineoplastic Agents, PhytogenicCyclohexanonesAmbuic acidAntiproliferativeEndophytic fungiMyrsinaceaeMyrsine sandwicensisPestalotiopsis

Identifiers

PMID28463686
PMCPMC5542815
OpenAlexW2624510561

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.