ArticleTissue engineering. Part A2018
Meniscal Tissue Engineering Using Aligned Collagen Fibrous Scaffolds: Comparison of Different Human Cell Sources.
Article in Tissue engineering. Part A, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
20 citing papers in PubMed, 41 citations in OpenAlex.
- Pneumatospinning and Electrospinning Scaffolds for Meniscus Regeneration Using Human Embryonic-Derived Mesenchymal Stem Cells.Bioengineering (Basel, Switzerland) · 2026Article
- Silk Fibroin-Based Hydrogels Supplemented with Decellularized Extracellular Matrix and Gelatin Facilitate 3D Bioprinting for Meniscus Tissue Engineering.Macromolecular bioscience · 2025Article
- Applications and prospects of different functional hydrogels in meniscus repair.Frontiers in bioengineering and biotechnology · 2022Review
- Pneumatospinning Biomimetic Scaffolds for Meniscus Tissue Engineering.Frontiers in bioengineering and biotechnology · 2022Article
- Natural biopolymer scaffold for meniscus tissue engineering.Frontiers in bioengineering and biotechnology · 2022Review
- Mesenchymal Stem Cells From Different Sources in Meniscus Repair and Regeneration.Frontiers in bioengineering and biotechnology · 2022Review
- Three-Dimensional-Printed Scaffolds for Meniscus Tissue Engineering: Opportunity for the Future in the Orthopaedic World.Journal of functional biomaterials · 2021Article
- Harnessing adipose stem cell diversity in regenerative medicine.APL bioengineering · 2021Review
- Collagen-Based Electrospun Materials for Tissue Engineering: A Systematic Review.Bioengineering (Basel, Switzerland) · 2021Review
- Surfactant location and internal phase volume fraction dictate emulsion electrospun fiber morphology and modulate drug release and cell response.Biomaterials science · 2021Article
- Meniscal Regenerative Scaffolds Based on Biopolymers and Polymers: Recent Status and Applications.Frontiers in cell and developmental biology · 2021Review
- Nanofiber Scaffolds by Electrospinning for Rotator Cuff Tissue Engineering.Chonnam medical journal · 2021Review
- Bioactive proteins delivery through core-shell nanofibers for meniscal tissue regeneration.Nanomedicine : nanotechnology, biology, and medicine · 2020Article
- Core-Shell Nanofibrous Scaffolds for Repair of Meniscus Tears.Tissue engineering. Part A · 2019Article
- Suturable regenerated silk fibroin scaffold reinforced with 3D-printed polycaprolactone mesh: biomechanical performance and subcutaneous implantation.Journal of materials science. Materials in medicine · 2019Article
- Hybrid Additive Microfabrication Scaffold Incorporated with Highly Aligned Nanofibers for Musculoskeletal Tissues.Tissue engineering and regenerative medicine · 2019Article
- Engineered Healing of Avascular Meniscus Tears by Stem Cell Recruitment.Scientific reports · 2018Article
- Modelling and Optimization of Polycaprolactone Ultrafine-Fibres Electrospinning Process Using Response Surface Methodology.Materials (Basel, Switzerland) · 2018Article
- Solvent retention in electrospun fibers affects scaffold mechanical properties.Electrospinning · 2018Article
- Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
Hydrogel and electrospun scaffold materials support cell attachment and neotissue development and can be tuned to structurally and mechanically resemble native extracellular matrix by altering either electrospun fiber or hydrogel properties. In this study, we examined meniscus tissue generation from different human cell sources including meniscus cells derived from vascular and avascular regions, human bone marrow-derived mesenchymal stem cells, synovial cells, and cells from the infrapatellar fat pad (IPFP). All cells were seeded onto aligned electrospun collagen type I scaffolds and were optionally encapsulated in a tricomponent hydrogel. Single or multilayered constructs were generated and cultivated in defined medium with selected growth factors for 2 weeks. Cell viability, cell morphology, and gene-expression profiles were monitored using confocal microscopy, scanning electron microscopy, and quantitative polymerase chain reaction (qPCR), respectively. Multilayered constructs were examined with histology, immunohistochemistry, qPCR, and for tensile mechanical properties. For all cell types, TGFβ1 and TGFβ3 treatment increased COL1A1, COMP, Tenascin C (TNC), and Scleraxis (SCX) gene expression and deposition of collagen type I protein. IPFP cells generated meniscus-like tissues with higher meniscogenic gene expression, mechanical properties, and better cell distribution compared to other cell types studied. We show proof of concept that electrospun collagen scaffolds support neotissue formation and IPFP cells have potential for use in cell-based meniscus regeneration strategies.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.