ArticleJournal of the American Chemical Society2017
Carba-cyclophellitols Are Neutral Retaining-Glucosidase Inhibitors.
Article in Journal of the American Chemical Society, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed, 25 citations in OpenAlex.
- Emerging gut microbial glycoside hydrolase inhibitors.RSC chemical biology · 2025Review
- Mechanism-Based Allylic Carbasugar Chlorides That Form Covalent Intermediates with α- and β-Galactosidases.Molecules (Basel, Switzerland) · 2024Article
- From Mechanism-Based Retaining Glycosidase Inhibitors to Activity-Based Glycosidase Profiling.Journal of the American Chemical Society · 2024Review
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- Rational Tuning of the Reactivity of Three-Membered Heterocycle Ring Openings via SChemistry (Weinheim an der Bergstrasse, Germany) · 2022Article
- Synthesis of broad-specificity activity-based probes forOrganic & biomolecular chemistry · 2022Article
- Synthesis of CFrontiers in chemistry · 2022Article
- Design, Synthesis and Structural Analysis of Glucocerebrosidase Imaging Agents.Chemistry (Weinheim an der Bergstrasse, Germany) · 2021Article
- Synthesis and Evaluation of Novel Iminosugars Prepared from Natural Amino Acids.Molecules (Basel, Switzerland) · 2021Article
- Amino Acid-Based Synthesis and Glycosidase Inhibition of Cyclopropane-Containing Iminosugars.ACS omega · 2020Article
- Glycoside hydrolase stabilization of transition state charge: new directions for inhibitor design.Chemical science · 2020Article
- A baculoviral system for the production of human β-glucocerebrosidase enables atomic resolution analysis.Acta crystallographica. Section D, Structural biology · 2020Article
- Defining the SACS central science · 2019Article
- Conformational Itinerary of Sucrose During Hydrolysis by Retaining Amylosucrase.Frontiers in chemistry · 2019Article
- Evaluating hydrophobic galactonoamidines as transition state analogs for enzymatic β-galactoside hydrolysis.Bioorganic chemistry · 2018Article
- 1,6-Cyclophellitol Cyclosulfates: A New Class of Irreversible Glycosidase Inhibitor.ACS central science · 2017Article
Corrections and comments
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Authors and funding
16 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The conformational analysis of glycosidases affords a route to their specific inhibition through transition-state mimicry. Inspired by the rapid reaction rates of cyclophellitol and cyclophellitol aziridine-both covalent retaining β-glucosidase inhibitors-we postulated that the corresponding carba "cyclopropyl" analogue would be a potent retaining β-glucosidase inhibitor for those enzymes reacting through the
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.