SynthesisTranslational psychiatry2017
Subcortical brain structure and suicidal behaviour in major depressive disorder: a meta-analysis from the ENIGMA-MDD working group.
Synthesis in Translational psychiatry, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers, 7 of them syntheses that pooled it.
What it found
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Who cites it
54 citing papers in PubMed, 7 syntheses or guidelines pooled it.
- A working model linking the psychopathology and pathophysiology of major depressive disorder - an umbrella review of neuroimaging studies and a conceptual framework.Molecular psychiatry · 2025Pooled it
- Cross disorder comparisons of brain structure in schizophrenia, bipolar disorder, major depressive disorder, and 22q11.2 deletion syndrome: A review of ENIGMA findings.Psychiatry and clinical neurosciences · 2022Pooled it
- Subcortical shape alterations in major depressive disorder: Findings from the ENIGMA major depressive disorder working group.Human brain mapping · 2022Pooled it
- ENIGMA + COINSTAC: Improving Findability, Accessibility, Interoperability, and Re-usability.Neuroinformatics · 2022Pooled it
- The ENIGMA Brain Injury working group: approach, challenges, and potential benefits.Brain imaging and behavior · 2021Pooled it
- Pooled it
- ENIGMA and global neuroscience: A decade of large-scale studies of the brain in health and disease across more than 40 countries.Translational psychiatry · 2020Pooled it
- Gray matter volume alterations in early-adulthood major depressive disorder patients with non-suicidal self-injury and suicide attempts.BMC psychiatry · 2026Article
- Brain Volume Reductions and Relationship With Depression and Cognitive Functioning in Suicide in Older Adults: A Cross-Sectional and Longitudinal Study Using Bayesian Multilevel Modeling.Biological psychiatry global open science · 2025Article
- Genetic Links Between Subcortical Brain Morphometry and Suicide Attempt Risk in Children and Adults.Human brain mapping · 2025Article
- 'Unravelling the shared genetic architecture between suicidality and subcortical brain volume: a genome-wide association study'.Acta neuropsychiatrica · 2025Article
- Structural brain changes in the anterior cingulate cortex of major depressive disorder individuals with suicidal ideation: Evidence from the REST-meta-MDD project.Psychological medicine · 2025Article
- Leptin's Inverse Association With Brain Morphology and Depressive Symptoms: A Discovery and Confirmatory Study Across 2 Independent Samples.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2024Article
- Connectome architecture modulates the gray matter atrophy in major depression disorder patients with diverse suicidal ideations.Brain imaging and behavior · 2024Article
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- Article
- Suicide risk in patients with a current depressive episode during the COVID-19 pandemic.Frontiers in psychiatry · 2024Article
- Neuroimaging-based classification of PTSD using data-driven computational approaches: A multisite big data study from the ENIGMA-PGC PTSD consortium.NeuroImage · 2023Article
- Connectomics-based resting-state functional network alterations predict suicidality in major depressive disorder.Translational psychiatry · 2023Article
- Event-Related Potential Markers of Suicidality in Adolescents.The international journal of neuropsychopharmacology · 2023Article
Corrections and comments
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Authors and funding
37 authors.
Funding
Abstract
The aetiology of suicidal behaviour is complex, and knowledge about its neurobiological mechanisms is limited. Neuroimaging methods provide a noninvasive approach to explore the neural correlates of suicide vulnerability in vivo. The ENIGMA-MDD Working Group is an international collaboration evaluating neuroimaging and clinical data from thousands of individuals collected by research groups from around the world. Here we present analyses in a subset sample (n=3097) for whom suicidality data were available. Prevalence of suicidal symptoms among major depressive disorder (MDD) cases ranged between 29 and 69% across cohorts. We compared mean subcortical grey matter volumes, lateral ventricle volumes and total intracranial volume (ICV) in MDD patients with suicidal symptoms (N=451) vs healthy controls (N=1996) or MDD patients with no suicidal symptoms (N=650). MDD patients reporting suicidal plans or attempts showed a smaller ICV (P=4.12 × 10
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