Evidence map›Paper›PMID 28463086›Full record

ArticleAmerican journal of respiratory cell and molecular biology2017

Vitamin D Counteracts an IL-23-Dependent IL-17A

Elizabeth H Mann, Tzer-Ren Ho, Paul E Pfeffer, Nick C Matthews, Elfy Chevretton, Ian Mudway, Frank J Kelly, Catherine M Hawrylowicz

Open access · greenAbstract read
In one paragraph

Article in American journal of respiratory cell and molecular biology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed, 1 pooled it
3.0field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 1 synthesis or guideline pooled it, 38 citations in OpenAlex.

  1. Ambient air pollution exposure, mediating biomarkers and risk of COPD: a cohort study and meta-analysis.European respiratory review : an official journal of the European Respiratory Society · 2025
    Pooled it
  2. Article
  3. Review
  4. Review
  5. Review
  6. Vitamin D Supplementation, Long-Term PMAmerican journal of respiratory and critical care medicine · 2025
    Article
  7. Article
  8. Review
  9. Article
  10. Review
  11. Article
  12. Article
  13. Article
  14. Review
  15. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 1 country.

Elizabeth H Mann1 MRC and Asthma-UK Centre for Allergic Mechanisms in Asthma, and.
Tzer-Ren Ho1 MRC and Asthma-UK Centre for Allergic Mechanisms in Asthma, and.
Paul E Pfeffer1 MRC and Asthma-UK Centre for Allergic Mechanisms in Asthma, and.
Nick C Matthews1 MRC and Asthma-UK Centre for Allergic Mechanisms in Asthma, and.
Elfy Chevretton2 Department of ENT Services, Guy's and St Thomas' NHS Foundation Trust, London, United Kingdom.
Ian Mudway3 Environmental Research Group, MRC-PHE Centre for Environment and Health, King's College London, London, United Kingdom; and.
Frank J Kelly1 MRC and Asthma-UK Centre for Allergic Mechanisms in Asthma, and.
Catherine M Hawrylowicz1 MRC and Asthma-UK Centre for Allergic Mechanisms in Asthma, and.
Asthma UK · GBKing's College London · GBGuy's and St Thomas' NHS Foundation Trust · GBQueen Mary University of London · GB

Funding

Medical Research Council G1000758Medical Research Council MR/L01341X/1Wellcome Trust
6 · The paper itself

Abstract

Urban particulate matter (UPM) air pollution and vitamin D deficiency are detrimentally associated with respiratory health. This is hypothesized to be due in part to regulation of IL-17A, which UPM is reported to promote. Here, we used a myeloid dendritic cell (DC)-memory CD4

Indexed as

CitiesCalcitriolCell DifferentiationDendritic CellsDexamethasoneHumansInterferon-gammaInterleukin-17Interleukin-23Myeloid CellsParticulate MatterPhenotypeTh17 CellsUp-RegulationVitamin DCalcitriolDexamethasoneIL17A protein, humanInterferon-gammaInterleukin-17Interleukin-23Particulate MatterVitamin Dair pollutioncorticosteroidsIL-23Th17vitamin D

Identifiers

PMID28463086
PMCPMC5625227
OpenAlexW2610395373

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.