ArticleScientific reports2017
Nanoporous mannitol carrier prepared by non-organic solvent spray drying technique to enhance the aerosolization performance for dry powder inhalation.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- Development of Spray-Dried Mannitol-Pregelatinized Rice Starch Using SeDeM-Based Approach for Direct Compressible Cetirizine Dihydrochloride Tablets.Pharmaceutics · 2025Article
- Engineering Large Porous Mannitol-PVA Microparticles for Extended Drug Delivery via Spray Drying.Pharmaceutics · 2025Article
- Lung Delivery of Lactose-Free Microparticles Loaded with Azithromycin for the Treatment of Bacterial Infections.Pharmaceutics · 2025Article
- Faster efficacy and reduced nodule occurrence with PLLA (poly-l-lactic acid) porous microspheres.Frontiers in bioengineering and biotechnology · 2025Article
- Development of Large Hollow Particles for Pulmonary Delivery of Cyclosporine A.Pharmaceutics · 2023Article
- Corrugated surface microparticles with chitosan and levofloxacin for improved aerodynamic performance.Asian journal of pharmaceutical sciences · 2023Article
- Low Drug Loading Hampers the Clinical Translation of Peptide Drugs-Containing Metered-Dose Inhalers.Pharmaceuticals (Basel, Switzerland) · 2022Article
- A real-time and modular approach for quick detection and mechanism exploration of DPIs with different carrier particle sizes.Acta pharmaceutica Sinica. B · 2022Article
- Inhalable Nano-Dimpled Microspheres Containing Budesonide-PLGA for Improved Aerodynamic Performance.International journal of nanomedicine · 2022Article
- Inhalable Microparticles Embedding Calcium Phosphate Nanoparticles for Heart Targeting: The Formulation Experimental Design.Pharmaceutics · 2021Article
- The effect of ethanol on the habit andAsian journal of pharmaceutical sciences · 2021Article
- Nanoparticle-mediated macrophage targeting-a new inhalation therapy tackling tuberculosis.Drug delivery and translational research · 2021Article
- Novel approach for real-time monitoring of carrier-based DPIs delivery processActa pharmaceutica Sinica. B · 2020Article
- Understanding the effect of lipid formulation loading and ethanol as a diluent on solidification of pitavastatin super-saturable SNEDDS using factorial design approach.Research in pharmaceutical sciences · 2019Article
- Moisture-Resistant Co-Spray-Dried Netilmicin with l-Leucine as Dry Powder Inhalation for the Treatment of Respiratory Infections.Pharmaceutics · 2018Article
- Chitosan-based binary dry powder inhaler carrier with nanometer roughness for improving in vitro and in vivo aerosolization performance.Drug delivery and translational research · 2018Article
- Fragmented particles containing octreotide acetate prepared by spray drying technique for dry powder inhalation.Drug delivery and translational research · 2018Article
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Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
An optimum carrier rugosity is essential to achieve a satisfying drug deposition efficiency for the carrier based dry powder inhalation (DPI). Therefore, a non-organic spray drying technique was firstly used to prepare nanoporous mannitol with small asperities to enhance the DPI aerosolization performance. Ammonium carbonate was used as a pore-forming agent since it decomposed with volatile during preparation. It was found that only the porous structure, and hence the specific surface area and carrier density were changed at different ammonium carbonate concentration. Furthermore, the carrier density was used as an indication of porosity to correlate with drug aerosolization. A good correlation between the carrier density and fine particle fraction (FPF) (r
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