ArticleNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology2017
Chronic Nicotine Alters Corticostriatal Plasticity in the Striatopallidal Pathway Mediated By NR2B-Containing Silent Synapses.
Article in Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
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Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it, 27 citations in OpenAlex.
- Comparative disease risks associated with cigarette smoking and use of moist smokeless tobacco and snus: an umbrella review of epidemiological evidence from the United States and Western Europe.BMC public health · 2025Pooled it
- Dietary regulation of silent synapses in the dorsolateral striatum.Neuroscience · 2024Article
- Cofilin linked to GluN2B subunits of NMDA receptors is required for behavioral sensitization by changing the dendritic spines of neurons in the caudate and putamen after repeated nicotine exposure.Behavioral and brain functions : BBF · 2024Article
- DIETARY REGULATION OF SILENT SYNAPSES IN THE DORSOLATERAL STRIATUM.bioRxiv : the preprint server for biology · 2024Article
- Corticospinal circuit neuroplasticity may involve silent synapses: Implications for functional recovery facilitated by neuromodulation after spinal cord injury.IBRO neuroscience reports · 2023Article
- Acute and protracted abstinence from methamphetamine bidirectionally changes intrinsic excitability of indirect pathway spiny projection neurons in the dorsomedial striatum.Scientific reports · 2022Article
- Relapse-like behavior and nAChR sensitization following intermittent access nicotine self-administration.Neuropharmacology · 2022Article
- Acute and chronic effects by nicotine on striatal neurotransmission and synaptic plasticity in the female rat brain.Frontiers in molecular neuroscience · 2022Article
- Chronic nicotine impairs sparse motor learning via striatal fast-spiking parvalbumin interneurons.Addiction biology · 2021Article
- NOX1/NADPH Oxidase Promotes Synaptic Facilitation Induced by Repeated DThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Cellular and Molecular Changes in Hippocampal Glutamate Signaling and Alterations in Learning, Attention, and Impulsivity Following Prenatal Nicotine Exposure.Molecular neurobiology · 2020Article
- Plasticity in the Brainstem: Prenatal and Postnatal Experience Can Alter Laterodorsal Tegmental (LDT) Structure and Function.Frontiers in synaptic neuroscience · 2020Article
- Dorsolateral striatal miR-134 modulates excessive methamphetamine intake in self-administering rats.Metabolic brain disease · 2019Article
- Dopamine and addiction: what have we learned from 40 years of research.Journal of neural transmission (Vienna, Austria : 1996) · 2019Review
- Generation of silent synapses in dentate gyrus correlates with development of alcohol addiction.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2018Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Smoking is the leading cause of preventable death in the United States and success rates for quitting remain low. High relapse rates are attributed to pervasive nicotine-reinforced associative learning of incentive cues that is highly resistant to extinction. Why such learning is so persistent is poorly understood but may arise as a consequence of neuroadaptations in synaptic plasticity induced by chronic nicotine. We used whole-cell patch clamp recording to investigate the effect of chronic nicotine (cNIC) on synaptic plasticity in dopamine D2 receptor-expressing medium-spiny neurons in the indirect, striatopallidal pathway in dorsolateral striatum. Mice exposed to cNIC exhibited long-term potentiation in response to high-frequency stimulation instead of the expected depression. cNIC decreased baseline AMPA/NMDA ratio, arising from increased NMDA currents enriched in the NR2B subunit with a concomitant upregulation of NMDA-only, silent synapses. These data demonstrate that cNIC can increase silent synapses in MSNs, as observed with cocaine and opiates, and alter the regulation of corticostriatal plasticity. Prior work has characterized cocaine- and morphine-induced upregulation of silent synapses in the ventral striatum; we show it can occur in the dorsal striatum, a region associated with later stages of addiction, craving, and cue-induced relapse.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.