ArticleDevelopment and psychopathology2017
Determinants of neonatal brain-derived neurotrophic factor and association with child development.
Article in Development and psychopathology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 30 citations in OpenAlex.
- Neurotrophic Factor Levels in Preterm Infants: A Systematic Review and Meta-Analysis.Frontiers in neurology · 2021Pooled it
- Postnatal serum IGF-1 levels associate with brain volumes at term in extremely preterm infants.Pediatric research · 2023Trial
- Inflammatory Biomarkers and Neurotrophic Factors in Preterm Newborns as Predictors of Motor Development: A Systematic Review.Pediatric reports · 2026Review
- Breast Milk and Brain: The Influence of Iodine and Neurotrophic and Growth Factors on Children's Neurodevelopment-A Secondary Analysis.Journal of family & reproductive health · 2025Article
- DNA Methylation, Inflammation, and Neurobehavior in Preterm Infants.Biological research for nursing · 2024Article
- Caffeine: The Story beyond Oxygen-Induced Lung and Brain Injury in Neonatal Animal Models-A Narrative Review.Antioxidants (Basel, Switzerland) · 2024Review
- Prenatal and Childhood Smoke Exposure Associations with Cognition, Language, and Attention-Deficit/Hyperactivity Disorder.The Journal of pediatrics · 2023Article
- Review
- Brain-Derived Neurotrophic Factor Levels in Cord Blood from Growth Restricted Fetuses with Doppler Alteration Compared to Adequate for Gestational Age Fetuses.Medicina (Kaunas, Lithuania) · 2022Article
- Increased Brain-Derived Neurotrophic Factor Levels in Cerebrospinal Fluid During the Acute Phase in TBI-Induced Mechanical Allodynia in the Rat Model.Journal of pain research · 2022Article
- Review
- Neonatal brain volume as a marker of differential susceptibility to parenting quality and its association with neurodevelopment across early childhood.Developmental cognitive neuroscience · 2020Article
- Brain-Derived Neurotrophic Factor: A Promising Biomarker for Predicting Prematurity-Related Complications.International journal of preventive medicine · 2019Article
- Autonomic nervous system development and its impact on neuropsychiatric outcome.Pediatric research · 2019Review
- Among Children Born Extremely Preterm a Higher Level of Circulating Neurotrophins Is Associated with Lower Risk of Cognitive Impairment at School Age.The Journal of pediatrics · 2018Observational
- Intergenerational Sex-Specific Transmission of Maternal Social Experience.Scientific reports · 2018Article
- Plasma Brain-Derived Neurotrophic Factor Levels in Newborn Infants with Neonatal Abstinence Syndrome.Frontiers in pediatrics · 2017Article
- The Effects of Hesperidin on BDNF/TrkB Signaling Pathway and Oxidative Stress Parameters in the Cerebral Cortex of the Utero-placental Insufficiency Fetal Rat Model.Basic and clinical neuroscienceArticle
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
Abstract
Using a population-based birth cohort in upstate New York (2008-2010), we examined the determinants of brain-derived neurotrophic factor (BDNF) measured in newborn dried blood spots (n = 2,637). We also examined the association between neonatal BDNF and children's development. The cohort was initially designed to examine the influence of infertility treatment on child development but found no impact. Mothers rated children's development in five domains repeatedly through age 3 years. Socioeconomic and maternal lifestyle determinants of BDNF were examined using multivariable linear regression models. Generalized linear mixed models estimated odds ratios for neonatal BDNF in relation to failing a developmental domain. Smoking and drinking in pregnancy, nulliparity, non-White ethnicity/race, and prepregnancy obesity were associated with lower neonatal BDNF. Neonatal BDNF was not associated with failure for developmental domains; however, there was an interaction between BDNF and preterm birth. In preterm infants, a higher BDNF was associated with lower odds of failing any developmental domains, after adjusting for confounders and infertility treatment. This result was particularly significant for failure in communication. Our findings suggest that BDNF levels in neonates may be impacted by maternal lifestyle characteristics. More specifically, lower neonatal BDNF might be an early marker of aberrant neurodevelopment in preterm infants.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.