SynthesisAnnals of the Royal College of Surgeons of England2017
Laboratory risk indicator for necrotising fasciitis (LRINEC) score for the assessment of early necrotising fasciitis: a systematic review of the literature.
Synthesis in Annals of the Royal College of Surgeons of England, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 87 papers, 4 of them syntheses that pooled it.
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Who cites it
87 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- S1 Guideline on Infected Interdigital Intertrigo (also called Gram-Negative Toe Web Infection).Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG · 2026Guideline
- Necrotizing Fasciitis-Severe Complication of Bullous Pemphigoid: A Systematic Review, Risk Factors, and Treatment Challenges.Medicina (Kaunas, Lithuania) · 2023Pooled it
- Anorectal emergencies: WSES-AAST guidelines.World journal of emergency surgery : WJES · 2021Pooled it
- A systematic review of necrotising fasciitis in children from its first description in 1930 to 2018.BMC infectious diseases · 2019Pooled it
- The PH score for early differentiation of necrotizing fasciitis: a retrospective diagnostic prediction study.Infection · 2026Article
- Prognostic value of inflammatory and metabolic markers in Fournier's gangrene: a single-center retrospective analysis.Ulusal travma ve acil cerrahi dergisi = Turkish journal of trauma & emergency surgery : TJTES · 2026Article
- Recognizing Descending Necrotizing Mediastinitis in Adults: A Narrative Review of Diagnostic Dilemmas and Barriers.Cureus · 2026Review
- Necrotizing Fasciitis in Northern Italy: Clinical Characteristics, Risk Factors, and Prognostic Value of the LRINEC Score-A Single-Center Retrospective Case Series.Infectious disease reports · 2026Article
- Association between procalcitonin and mortality in patients with necrotizing fasciitis: A single-center retrospective study.JPRAS open · 2026Article
- Periocular necrotizing fasciitis following surgical site infection in aesthetic rhinoplasty: a report of two cases.Journal of ophthalmic inflammation and infection · 2026Article
- Periorbital infections caused by Group A streptococci: a case series.BMC infectious diseases · 2026Article
- Predictive score for cervicofacial cellulitis severity: development and validation of a multidisciplinary tool in Sub-Saharan Africa.BMC infectious diseases · 2026Observational
- Diagnostic strategies in necrotizing soft tissue infections: from clinical scores to multi-omics and machine learning.Burns & trauma · 2026Review
- Indocyanine green fluorescence-guided surgery in acute settings: state-of-the art.Frontiers in surgery · 2026Review
- Fulminant group A streptococcal necrotizing fasciitis presenting as severe calf pain after pharyngitis in an adolescent: a case report.Frontiers in medicine · 2026Article
- Article
- Deep Neck Infections: Treatment, Biological Predictive Factors and Outcome in 111 Patients.Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India · 2025Article
- Article
- Predictive Models for Necrotizing Soft Tissue Infections: Are the Available Scores Trustable?Journal of clinical medicine · 2025Review
- Necrotizing Fasciitis Caused by Gas-producing Methicillin-sensitive Staphylococcus aureus: A Case Report.Journal of orthopaedic case reports · 2025Article
27 more citing papers are in PubMed but not listed here.
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Introduction Early operative debridement of necrotising fasciitis is a major outcome determinant. Identification and diagnosis of such patients can be clinically difficult. The Laboratory Risk Indicator for Necrotising Fasciitis (LRINEC) score first published in 2004 is based on routinely performed parameters and offers a method for identifying early cases. No literature review has yet been performed on the application of such a score. Methods A systematic review of English-language literature was performed from 2004 to 2014 to identify articles reporting use of LRINEC score and the incidence of necrotising fasciitis. We performed a critical review of PubMed, Medline and Embase in line with the PRISMA statement. A meta-analysis was performed with a random effects model and 95% confidence interval. Suitable correlation coefficient and receiver operating characteristic (ROC) curves were also calculated. Results After application of inclusion criteria, 16 studies with 846 patients were included. The mean LRINEC score in patients with necrotising fasciitis was 6.06. Two papers reported LRINEC score in patients without necrotising fasciitis with a mean 2.45. All six studies with a reported coefficient of variance were < 1; Pearson correlation coefficient was r = 0.637 (P = 0.011). An ROC curve showed an area under the curve of 0.927. Conclusions The LRINEC score is a useful clinical determinant in the diagnosis and surgical treatment of patients with necrotising fasciitis, with a statistically positive correlation between LRINEC score and a true diagnosis of necrotising fasciitis.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.