Evidence map›Paper›PMID 28462430›Full record

ArticleEuropean journal of clinical pharmacology2017

Rational use of medicine in dentistry: do dentists prescribe antibiotics in appropriate indications?

Cenker Z Koyuncuoglu, Mehtap Aydin, N Ipek Kirmizi, Volkan Aydin, Mesil Aksoy, Fatma Isli, Ahmet Akici

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Article in European journal of clinical pharmacology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
40citing papers in PubMed, 1 pooled it
1.8field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

40 citing papers in PubMed, 1 synthesis or guideline pooled it, 75 citations in OpenAlex.

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  18. Assessment of knowledge, attitude, and practice of antibiotics prescription among healthcare residents at King Abdulaziz medical City, Jeddah, Saudi Arabia.Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 1 country.

Cenker Z KoyuncuogluDepartment of Periodontology, Faculty of Dentistry, Istanbul Aydin University, Istanbul, Turkey.
Mehtap AydinDepartment of Infectious Diseases and Clinical Microbiology, Faculty of Medicine, Baskent University, Istanbul, Turkey.
N Ipek KirmiziDepartment of Medical Pharmacology, Faculty of Medicine, Marmara University, Istanbul, Turkey.
Volkan AydinDepartment of Medical Pharmacology, Faculty of Medicine, Marmara University, Istanbul, Turkey.
Mesil AksoyTurkish Medicines and Medical Devices Agency, Ministry of Health, Ankara, Turkey.
Fatma IsliTurkish Medicines and Medical Devices Agency, Ministry of Health, Ankara, Turkey.
Ahmet AkiciDepartment of Medical Pharmacology, Faculty of Medicine, Marmara University, Istanbul, Turkey. aakici@marmara.edu.tr.ORCID http://orcid.org/0000-0002-8593-0818
Marmara University · TRMinistry of Health · TRBaşkent University · TRIstanbul Aydın University · TR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeThere are concerns regarding appropriate use of antibiotics in dentistry practice. Data on dental antibiotic prescribing patterns by dentists is relatively limited. This nationwide study aimed to examine dentists' antibiotic prescriptions in a diagnosis-based manner in Turkey.

methodsThis retrospective study on utilization of systemic antibiotics for dental problems was based on the national health data of the dentists obtained from Prescription Information System between January 2013 and August 2015. Only those prescriptions containing single diagnosis and at least one systemic antibiotic were included in the study. Antibiotic prescribing was compared by diagnoses and expertise of dentists.

resultsA total of 9,293,410 antibiotics were detected in 9,214,956 prescriptions that contained "single diagnosis and at least one antibiotic." The number of antibiotics per prescription was 1.01. "Periapical abscess without sinus" (28.1%), "dental examination" (20.7%), and "dental caries" (16.2%) were the three most common indications in which antibiotics were prescribed by dentists. While only 3.4% of antibiotics were prescribed upon the single and appropriate "cellulitis and abscess of mouth" diagnosis, the remaining 96.6% was prescribed for irrational/uncertain indications. Consistent in all diagnoses, "amoxicillin + enzyme inhibitor" (58.6%) was the mainly prescribed antibiotic. Analysis of the most preferred "amoxicillin + enzyme inhibitor" prescriptions by expertise of dentists showed significantly much higher prescription rates among Group A specialists and Group B specialists (67.0 and 67.8%, respectively) than those in unidentified dental practitioners (58.2%, p < 0.0001).

conclusionsThis study showed that dentists prescribed antibiotics in an arbitrary and mostly unnecessary manner. In general, their antibiotic choices for examined diagnoses could be regarded as irrational. These results indicate the urgent need for improvement of rational antibiotic prescribing habits of dentists.

Indexed as

Anti-Bacterial AgentsDentistryDentistsDrug UtilizationHumansInappropriate PrescribingPractice Patterns, Physicians'TurkeyAnti-Bacterial AgentsAntibiotic prescribingDental indicationsDentistryRational pharmacotherapy

Identifiers

PMID28462430
OpenAlexW2610360279

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.