ArticleIntegrative medicine research2017
Antihypertensive effect of allicin in dexamethasone-induced hypertensive rats.
Article in Integrative medicine research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
9 citing papers in PubMed, 1 synthesis or guideline pooled it, 45 citations in OpenAlex.
- Effects ofFrontiers in pharmacology · 2022Pooled it
- Naturally Occurring HHandbook of experimental pharmacology · 2026Review
- Beneficial Effects of White Grape Pomace in Experimental Dexamethasone-Induced Hypertension.Diseases (Basel, Switzerland) · 2025Article
- Influence of Synthesis Temperature on the Structural, Morphological and Optical Properties of MoOJournal of fluorescence · 2024Article
- Garlic against Heart-related Ailments: Chemistry, Pharmacology, and Future Perspective.Mini reviews in medicinal chemistry · 2024Review
- Apitherapy combination improvement of blood pressure, cardiovascular protection, and antioxidant and anti-inflammatory responses in dexamethasone model hypertensive rats.Scientific reports · 2022Article
- Potential Effects of Natural HBiomolecules · 2022Review
- Chemical Constituents and Pharmacological Activities of Garlic (Nutrients · 2020Review
- Allicin Improves Metabolism in High-Fat Diet-Induced Obese Mice by Modulating the Gut Microbiota.Nutrients · 2019Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundGlucocorticoid is among the most commonly prescribed medicine. Unfortunately, Excess glucocorticoid level leads hypertension in 80-90% patients. Garlic (Allium sativum) has been used since ancient times and even nowadays as a part of popular medicine for various ailments and physiological disorders. Hence this study was undertaken to investigate the antihypertensive activity of allicin in dexamethasone induced hypertension in wistar rats.
methodsThe animals were randomly divided into four groups comprising of six rats per group. Hypertension was induced by subcutaneous injection of dexamethasone (10 μg/rat/day) in hypertensive rats. Two hypertensive group animals were treated with nicorandil (6 mg/kg/day, po) and allicin (8 mg/kg/day, po) respectively for 8 weeks. While systolic blood pressure (SBP) was measured by the tail-cuff method weekly up to 8 weeks.
resultsDexamethasone treatment resulted in significant increase in SBP while allicin treatment significantly decreases the SBP. Thus, this study confirmed that allicin treatment for 8 weeks partially reverse dexamethasone induced hypertension in rats. Allicin treatment also attenuated dexamethasone-induced anorexia and loss of total body weight.
conclusionThis result suggests antihypertensive effects of allicin in dexamethasone induced hypertension. However, further studies are needed to explore the detailed mechanism of antihypertensive effect of allicin.
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