Evidence map›Paper›PMID 28462117›Full record

ReviewIntegrative medicine research2016

Function of specialized regulatory proteins and signaling pathways in exercise-induced muscle mitochondrial biogenesis.

Avigail T Erlich, Liam D Tryon, Matthew J Crilly, Jonathan M Memme, Zahra S Mesbah Moosavi, Ashley N Oliveira, Kaitlyn Beyfuss, David A Hood

Abstract readReview
In one paragraph

Review in Integrative medicine research, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Rethinking Osteoporosis Drugs: Can We Simultaneously Address Sarcopenia?International journal of molecular sciences · 2025
    Review
  5. Article
  6. Review
  7. Physical Activity and Oxidative Stress in Aging.Antioxidants (Basel, Switzerland) · 2024
    Review
  8. Synergistic Effects of Nigella sativa and Exercise on Diabetic Profiles: A Systematic Review.Diabetes therapy : research, treatment and education of diabetes and related disorders · 2023
    Review
  9. Article
  10. Review
  11. Article
  12. Review
  13. Review
  14. Article
  15. Review
  16. Review
  17. Review
  18. Review
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Avigail T ErlichMuscle Health Research Centre, School of Kinesiology and Health Science, York University, Toronto, Ontario M3J1P3, Canada.
Liam D TryonMuscle Health Research Centre, School of Kinesiology and Health Science, York University, Toronto, Ontario M3J1P3, Canada.
Matthew J CrillyMuscle Health Research Centre, School of Kinesiology and Health Science, York University, Toronto, Ontario M3J1P3, Canada.
Jonathan M MemmeMuscle Health Research Centre, School of Kinesiology and Health Science, York University, Toronto, Ontario M3J1P3, Canada.
Zahra S Mesbah MoosaviMuscle Health Research Centre, School of Kinesiology and Health Science, York University, Toronto, Ontario M3J1P3, Canada.
Ashley N OliveiraMuscle Health Research Centre, School of Kinesiology and Health Science, York University, Toronto, Ontario M3J1P3, Canada.
Kaitlyn BeyfussMuscle Health Research Centre, School of Kinesiology and Health Science, York University, Toronto, Ontario M3J1P3, Canada.
David A HoodMuscle Health Research Centre, School of Kinesiology and Health Science, York University, Toronto, Ontario M3J1P3, Canada.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Skeletal muscle mitochondrial content and function are regulated by a number of specialized molecular pathways that remain to be fully defined. Although a number of proteins have been identified to be important for the maintenance of mitochondria in quiescent muscle, the requirement for these appears to decrease with the activation of multiple overlapping signaling events that are triggered by exercise. This makes exercise a valuable therapeutic tool for the treatment of mitochondrially based metabolic disorders. In this review, we summarize some of the traditional and more recently appreciated pathways that are involved in mitochondrial biogenesis in muscle, particularly during exercise.

Indexed as

mitochondrial protein importPGC-1alphaskeletal muscleunfolded protein response

Identifiers

PMID28462117
PMCPMC5390460

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.