Evidence map›Paper›PMID 28462093›Full record

ArticleIntegrative medicine research2016

Mathematical analysis of the effects of valvular regurgitation on the pumping efficacy of continuous and pulsatile left ventricular assist devices.

Yoo Seok Kim, Eun-Hye Kim, Hyeong-Gyun Kim, Eun Bo Shim, Kwang-Soup Song, Ki Moo Lim

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Integrative medicine research, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.5field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 11 citations in OpenAlex.

  1. Review
  2. Review
  3. A step from the physiology to the physiome.Integrative medicine research · 2016
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Yoo Seok KimDepartment of Medical IT Convergence Engineering, Kumoh National Institute of Technology, Gumi, Korea.
Eun-Hye KimDepartment of Medical IT Convergence Engineering, Kumoh National Institute of Technology, Gumi, Korea.
Hyeong-Gyun KimDepartment of Radiological Science, Far East University, Eumseong, Korea.
Eun Bo ShimDepartment of Mechanical and Biomedical Engineering, Kangwon National University, Chuncheon, Korea.
Kwang-Soup SongDepartment of Medical IT Convergence Engineering, Kumoh National Institute of Technology, Gumi, Korea.
Ki Moo LimDepartment of Medical IT Convergence Engineering, Kumoh National Institute of Technology, Gumi, Korea.
Kumoh National Institute of Technology · KRFar East University · KRKangwon National University · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundA left ventricular assist device (LVAD) is normally contraindicated in significant aortic regurgitation (AR) and requires intraoperative valve repair or exclusion. Nevertheless, AR can coexist with an LVAD, so a valid question when asked might still be of clinical significance. The purpose of this study is to analyze the effects of valve regurgitation on the pumping efficacy of continuous and pulsatile LVADs with a computational method.

methodsA cardiovascular model was developed based on the Windkessel model, which reflects the hemodynamic flow resistance and the blood wall elasticity. Using the Windkessel model, important cardiovascular components, such as the right atrium, right ventricle, pulmonary artery, pulmonary vein, left atrium (LA), left ventricle (LV), aorta, and branching blood vessels, were expressed.

resultsIn the case of AR, continuous and pulsatile LVADs improved cardiac output and reduced mechanical load slightly. In the case of mitral regurgitation, the LVADs improved cardiac output (cardiac outputs were about 5 L/min regardless of the severity of regurgitation) and reduced afterload significantly.

conclusionAR reduced both continuous and pulsatile LVAD function significantly while mitral regurgitation did not affect their pumping efficacy.

Indexed as

aortic regurgitationleft ventricular assist devicemitral regurgitationregurgitation severityWindkessel model

Identifiers

PMID28462093
PMCPMC5381421
OpenAlexW2232853443

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.