ArticleNeuroImage. Clinical2017
Predicting cognitive behavioral therapy response in social anxiety disorder with anterior cingulate cortex and amygdala during emotion regulation.
Article in NeuroImage. Clinical, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed, 64 citations in OpenAlex.
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- Supportive neural mechanisms underlying successful emotion regulation for reappraisal success.Scientific reports · 2026Article
- Neural predictors of treatment outcome through emotion regulation in internalizing disorders: a narrative review.Translational psychiatry · 2026Review
- Visually grounded emotion regulation via diffusion models and user-driven reappraisal.Frontiers in artificial intelligence · 2026Article
- Abscisic Acid Rescues Behavior in Adult Female Mice in Attention Deficit Disorder with Hyperactivity Model of Dopamine Depletion by Regulating Microglia and Increasing Vesicular GABA Transporter Expression.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2025Article
- The Shared and Distinct Mechanisms Underlying Fear of Evaluation in Social Anxiety: The Roles of Negative and Positive Evaluation.Depression and anxiety · 2025Review
- Trait anxiety and corresponding neuromarkers predict internet addiction: A longitudinal study.Journal of behavioral addictions · 2024Article
- A brain model of altered self-appraisal in social anxiety disorder.Translational psychiatry · 2023Article
- Social circuits and their dysfunction in autism spectrum disorder.Molecular psychiatry · 2023Review
- Individual cognitive therapy reduces frontal-thalamic resting-state functional connectivity in social anxiety disorder.Frontiers in psychiatry · 2023Article
- Neurocircuitry of treatment in anxiety disorders.Biomarkers in neuropsychiatry · 2022Article
- Anterior cingulate cortex activity during attentional control corresponds with rumination in depression and social anxiety.Psychiatry research. Neuroimaging · 2021Article
- Resting state functional connectivity correlates of rumination and worry in internalizing psychopathologies.Depression and anxiety · 2021Article
- Optogenetic Approaches to Understand the Neural Circuit Mechanism of Social Deficits Seen in Autism Spectrum Disorders.Advances in experimental medicine and biology · 2021Review
- Distinct neural engagement during implicit and explicit regulation of negative stimuli.Neuropsychologia · 2020Article
- Changes in functional connectivity with cognitive behavioral therapy for social anxiety disorder predict outcomes at follow-up.Behaviour research and therapy · 2020Article
- Imaging the socially-anxious brain: recent advances and future prospects.F1000Research · 2020Review
- Transdiagnostic neural correlates of volitional emotion regulation in anxiety and depression.Depression and anxiety · 2019Article
- Multidimensional imaging techniques for prediction of treatment response in major depressive disorder.Progress in neuro-psychopharmacology & biological psychiatry · 2019Article
- Reliability of Fronto-Amygdala Coupling during Emotional Face Processing.Brain sciences · 2019Article
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundCognitive Behavioral Therapy (CBT) for social anxiety disorder (SAD) and other internalizing conditions attempts to improve emotion regulation. Accumulating data indicate anterior cingulate cortex (ACC), and to a lesser extent amygdala, activation in various tasks predicts treatment outcome. However, little is known about ACC and amygdala activation to emotion regulation in predicting clinical improvement following CBT in SAD.
methodsBefore treatment, 38 SAD patients completed implicit and explicit emotion regulation paradigms during fMRI. Implicit regulation involved attentional control over negative distractors. Explicit regulation comprised cognitive reappraisal to negative images. Pre-CBT brain activity was circumscribed to anatomical-based ACC sub-regions (rostral, dorsal) and amygdala masks, which were submitted to ROC curves to examine predictive validity as well as correlational analysis to evaluate prognostic change in symptom severity.
resultsMore rostral (rACC) activity in implicit regulation and less rACC activity during explicit regulation distinguished responders (34%) from non-responders. Greater amygdala response in implicit regulation also foretold responder status. Baseline rACC and amygdala activity during attentional control correlated with pre-to-post CBT change in symptom severity such that more activation was related to greater decline in symptoms. No significant correlations were observed for explicit regulation.
conclusionsAcross forms of regulation, rACC activity predicted responder status whereas amygdala as a neuromarker was limited to implicit regulation. While the direction of effects (enhanced vs. reduced) in rACC activity was task-dependent, results suggest SAD patients with deficient regulation benefited more from CBT. Findings support previous studies involving patients with depression and suggest the rACC may be a viable marker of clinical improvement in SAD.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.