Evidence map›Paper›PMID 28462077›Full record

ArticleMolecular metabolism2017

PDK1-FoxO1 pathway in AgRP neurons of arcuate nucleus promotes bone formation via GHRH-GH-IGF1 axis.

Hideyuki Sasanuma, Masanori Nakata, Kumari Parmila, Jun Nakae, Toshihiko Yada

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular metabolism, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
0.9field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 20 citations in OpenAlex.

  1. Review
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  9. An evolutionary perspective on immunometabolism.Science (New York, N.Y.) · 2019
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Hideyuki SasanumaDepartment of Physiology, Division of Integrative Physiology, Jichi Medical University, 3311-1 Yakushiji, Tochigi, Shimotsuke, 329-0498, Japan; Department of Orthopaedic Surgery, Faculty of Medicine, Jichi Medical University, 3311-1 Yakushiji, Tochigi, Shimotsuke, 329-0498, Japan.
Masanori NakataDepartment of Physiology, Division of Integrative Physiology, Jichi Medical University, 3311-1 Yakushiji, Tochigi, Shimotsuke, 329-0498, Japan. Electronic address: nakata@jichi.ac.jp.
Kumari ParmilaDepartment of Physiology, Division of Integrative Physiology, Jichi Medical University, 3311-1 Yakushiji, Tochigi, Shimotsuke, 329-0498, Japan.
Jun NakaeFrontier Medicine on Metabolic Syndrome, Division of Endocrinology, Metabolism and Nephrology, Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan.
Toshihiko YadaDepartment of Physiology, Division of Integrative Physiology, Jichi Medical University, 3311-1 Yakushiji, Tochigi, Shimotsuke, 329-0498, Japan. Electronic address: tyada@jichi.ac.jp.
Jichi Medical University · JPKeio University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveIn the hypothalamic arcuate nucleus (ARC), orexigenic agouti-related peptide (AgRP) neurons regulate feeding behavior and energy homeostasis, functions connected to bone metabolism. The 3-phosphoinositide-dependent protein kinase-1 (PDK1) serves as a major signaling molecule particularly for leptin and insulin in AgRP neurons. We asked whether PDK1 in AGRP neurons also contributes to bone metabolism.

methodsWe generated AgRP neuron-specific PDK1 knockout (

resultsIn

conclusionsThis study reveals a novel role of PDK1-Foxo1 pathway of AgRP neurons in controlling bone metabolism primarily via GHRH-GH-IGF-1 axis.

Indexed as

Bone DensityOsteogenesisAgouti-Related ProteinAnimalsArcuate Nucleus of HypothalamusFemaleForkhead Box Protein O1Growth HormoneGrowth Hormone-Releasing HormoneInsulin-Like Growth Factor IMiceMice, Inbred C57BLNeuronsProtein Serine-Threonine KinasesPyruvate Dehydrogenase Acetyl-Transferring KinaseAgouti-Related ProteinForkhead Box Protein O1Foxo1 protein, mouseGrowth HormoneGrowth Hormone-Releasing HormoneInsulin-Like Growth Factor IPdk1 protein, mouseProtein Serine-Threonine KinasesPyruvate Dehydrogenase Acetyl-Transferring KinaseAgRPARC, arcuateBMD, bone mineral densityBone mineralizationFoxo1GHRHGHRH, Growth hormone releasing hormoneGrowth hormoneIGF-1, insulin-like growth factor-1PDK1PVN, paraventricular nucleus

Identifiers

PMID28462077
PMCPMC5404105
OpenAlexW2588831453

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.