ArticlePeerJ2017
Oxytetracycline induces DNA damage and epigenetic changes: a possible risk for human and animal health?
Article in PeerJ, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 35 citations in OpenAlex.
- Effect of a commercially available fish-based dog food enriched with nutraceuticals on hip and elbow dysplasia in growing Labrador retrievers.Canadian journal of veterinary research = Revue canadienne de recherche veterinaire · 2018Trial
- Multiple contaminant detection in commercially available chicken-based cat kibbles in Italy.Frontiers in veterinary science · 2026Article
- Screening of Chemical Residues and Antimicrobial Resistance in Dehydrated Chicken Feet Intended as Dog Treats: A Pilot Study.Veterinary medicine international · 2026Article
- Antibiotics induce overexpression of alpha satellite DNA accompanied with epigenetic changes at alpha satellite arrays as well as genome-wide.Epigenetics & chromatin · 2025Article
- Optimizing oxytetracycline removal from aqueous solutions using activated carbon from barley lignocellulosic wastes with isotherms and thermodynamic studies.Scientific reports · 2024Article
- Zinc Oxide Nanoparticles (ZnO-NPs) Induce Cytotoxicity in the Zebrafish Olfactory Organs via Activating Oxidative Stress and Apoptosis at the Ultrastructure and Genetic Levels.Animals : an open access journal from MDPI · 2023Article
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- Extender Supplementation with Glutathione (GSH) and Taurine ImprovesVeterinary medicine international · 2023Article
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- Characterization and Antibacterial Evaluation of Biodegradable Mannose-Conjugated Fe-MIL-88NHPolymers · 2022Article
- Effect of Chicken Bone Extracts on Metabolic and Mitochondrial Functions of K562 Cell Line.Pharmaceuticals (Basel, Switzerland) · 2020Article
- Sulfide (Na₂S) and Polysulfide (Na₂S₂) Interacting with Doxycycline Produce/Scavenge Superoxide and Hydroxyl Radicals and Induce/Inhibit DNA Cleavage.Molecules (Basel, Switzerland) · 2019Article
- Hypospermia Improvement in Dogs Fed on a Nutraceutical Diet.TheScientificWorldJournal · 2018Article
Corrections and comments
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Authors and funding
13 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundOxytetracycline (OTC), which is largely employed in zootechnical and veterinary practices to ensure wellness of farmed animals, is partially absorbed within the gastrointestinal tract depositing in several tissues. Therefore, the potential OTC toxicity is relevant when considering the putative risk derived by the entry and accumulation of such drug in human and pet food chain supply. Despite scientific literature highlights several OTC-dependent toxic effects on human and animal health, the molecular mechanisms of such toxicity are still poorly understood.
methodsHere, we evaluated DNA damages and epigenetic alterations by quantitative reverse transcription polymerase chain reaction, quantitative polymerase chain reaction, chromatin immuno-precipitation and Western blot analysis.
resultsWe observed that human peripheral blood mononuclear cells (PBMCs) expressed DNA damage features (activation of ATM and p53, phosphorylation of H2AX and modifications of histone H3 methylation of lysine K4 in the chromatin) after the DISCUSSION: Our data reveal an unexpected biological
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.