Differentiation of Human Pluripotent Stem Cells into Mesodermal and Ectodermal Derivatives Is Independent of the Type of Isogenic Reprogrammed Somatic Cells.

E S Philonenko, M V Shutova, E A Khomyakova, E M Vassina, O S Lebedeva, S L Kiselev, M A Lagarkova

Open access · hybridAbstract read

In one paragraph

Article in Acta naturae. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it

0cells of the map it votes in

4citing papers in PubMed

0.2field-weighted citation impact, top 44% of its field

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

Generation of Vascular Organoids from Human iPSCs to Study Neurodegenerative Processes.Bulletin of experimental biology and medicine · 2026
Article
Extracellular vesicles of human glial cells exert neuroprotective effects via brain miRNA modulation in a rat model of traumatic brain injury.Scientific reports · 2023
Article
Mesodermal Derivatives of Pluripotent Stem Cells Route to Scarless Healing.International journal of molecular sciences · 2023
Review
Predicting differentiation potential of human pluripotent stem cells: Possibilities and challenges.World journal of stem cells · 2019
Article

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

E S PhilonenkoVavilov Institute of General Genetics, Russian Academy of Sciences, Gubkina Str. 3, Moscow, 119333 , Russia.

M V ShutovaVavilov Institute of General Genetics, Russian Academy of Sciences, Gubkina Str. 3, Moscow, 119333 , Russia.

E A KhomyakovaVavilov Institute of General Genetics, Russian Academy of Sciences, Gubkina Str. 3, Moscow, 119333 , Russia.

E M VassinaVavilov Institute of General Genetics, Russian Academy of Sciences, Gubkina Str. 3, Moscow, 119333 , Russia.

O S LebedevaScientific Research Center of Physical-Chemical Medicine, Pirogovskaya Str. 1a, Moscow, 119435, Russia.

S L KiselevVavilov Institute of General Genetics, Russian Academy of Sciences, Gubkina Str. 3, Moscow, 119333 , Russia.

M A LagarkovaVavilov Institute of General Genetics, Russian Academy of Sciences, Gubkina Str. 3, Moscow, 119333 , Russia.

Research Institute of Physical Chemical Medicine · RUVavilov Institute of General Genetics · RU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Induced pluripotent stem cells (iPSCs) have the capacity to unlimitedly proliferate and differentiate into all types of somatic cells. This capacity makes them a valuable source of cells for research and clinical use. However, the type of cells to be reprogrammed, the selection of clones, and the various genetic manipulations during reprogramming may have an impact both on the properties of iPSCs and their differentiated derivatives. To assess this influence, we used isogenic lines of iPSCs obtained by reprogramming of three types of somatic cells differentiated from human embryonic stem cells. We showed that technical manipulations

Indexed as

hematopoiesishuman embryonic stem cellsinduced pluripotent stem cellsmethylationneuronstranscription

Identifiers

PMID28461976

PMCPMC5406662

OpenAlexW2742914161

What OpenQuestion holds

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LicenceCC BY

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.