ArticleEFORT open reviews2016
Aetiology and pathogenesis of bone marrow lesions and osteonecrosis of the knee.
Article in EFORT open reviews, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 44 citations in OpenAlex.
- The role of the AMPK/NLRP3 axis in osteoarthritic bone marrow lesions of the knee: from molecular mechanisms to clinical applications.Journal of molecular histology · 2026Review
- Relationships Among Bone Marrow Lesions, Cartilage Improvement, and Short- to Midterm Patient-Reported Outcomes After Opening-Wedge High Tibial Osteotomy.Orthopaedic journal of sports medicine · 2026Article
- Enhancing knee MRI bone marrow lesion detection with artificial intelligence: An external validation study.Research in diagnostic and interventional imaging · 2025Article
- Imaging of osteoarthritis-related bone marrow lesions in clinical trials.Osteoarthritis imaging · 2025Article
- Conservative treatments of bone marrow lesions.Journal of experimental orthopaedics · 2025Article
- A case of subchondral insufficiency fracture of the knee potentially caused by mediolateral knee laxity without structural abnormalities.BMC musculoskeletal disorders · 2025Article
- Bone marrow lesion and medial meniscus extrusion width changes following arthroscopic partial meniscectomy for medial meniscal flap tears.Journal of orthopaedic surgery and research · 2025Article
- A nosographic and etiopathogenetic framework for subchondral bone marrow lesions in the knee: A narrative review.Journal of experimental orthopaedics · 2025Article
- Subchondral bone: An emerging target for the treatment of articular surface lesions of the knee.Journal of experimental orthopaedics · 2024Review
- No Significant Differences between Bisphosphonates and Placebo for the Treatment of Bone Marrow Lesions of the Knee: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.Journal of clinical medicine · 2024Review
- Intraosseous Treatment of Bone Marrow Lesions in the Knee: Surgical Technique.Arthroscopy techniques · 2024Article
- Dual-energy CT: Impact of detecting bone marrow oedema in occult trauma in the Emergency.BJR open · 2024Review
- Larger bone marrow lesion volume before medial open-wedge high tibial osteotomy correlates with better improvement of clinical scores in patients with knee osteoarthritis.Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA · 2023Article
- Traumatic bone marrow lesions in dual-energy computed tomography.Insights into imaging · 2022Review
- Autologous stem cell implantation with core decompression for avascular necrosis of the femoral head using a new device.Annals of the Royal College of Surgeons of England · 2021Article
- A Retrospective Study of Unicompartmental Knee Arthroplasty Functional Outcome and the Incidence of Medial Meniscus Posterior Root Tear in Spontaneous Osteonecrosis of the Knee.BioMed research international · 2021Article
- Bone marrow lesions: etiology and pathogenesis at the hip.Journal of hip preservation surgery · 2020Review
- Zoledronic acid is more efficient than ibandronic acid in the treatment of symptomatic bone marrow lesions of the knee.Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA · 2020Article
- [Analysis of medial unicompartmental knee arthroplasty for patients with spontaneous osteonecrosis of the knee].Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery · 2019Article
- Hitting the Mark: Optimizing the Use of Calcium Phosphate Injections for the Treatment of Bone Marrow Lesions of the Proximal Tibia and Distal Femur.Arthroscopy techniques · 2018Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Bone marrow lesions (BML) of the knee are a frequent MRI finding, present in many different pathologies including trauma, post-cartilage surgery, osteoarthritis, transient BML syndromes, spontaneous insufficiency fractures, and true osteonecrosis.Osteonecrosis (ON) is in turn divided into spontaneous osteonecrosis (SONK), which is considered to be correlated to subchondral insufficiency fractures (SIFK), and avascular necrosis (AVN) which is mainly ascribable to ischaemic events.Every condition has a MRI pattern, a different clinical presentation, and specific histological features which are important in the differential diagnosis.The current evidence supports an overall correlation between BML and patient symptoms, although literature findings are variable, and very little is known about the natural history and the progression of these lesions.A full understanding of BML will be mandatory in the future to better address the different pathologies and develop appropriately-targeted treatments. Cite this article: Marcacci M, Andriolo L, Kon E, Shabshin N, Filardo G. Aetiology and pathogenesis of bone marrow lesions and osteonecrosis of the knee.
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