Evidence map›Paper›PMID 28461507›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2017

Evolutionarily conserved TRH neuropeptide pathway regulates growth in

Elien Van Sinay, Olivier Mirabeau, Geert Depuydt, Matthias Boris Van Hiel, Katleen Peymen, Jan Watteyne, Sven Zels, Liliane Schoofs, Isabel Beets

Open access · bronzeAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.

0numbers the graph read from it
0cells of the map it votes in
36citing papers in PubMed
3.5field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

36 citing papers in PubMed, 75 citations in OpenAlex.

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  17. ACS chemical neuroscience · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 2 countries.

Elien Van SinayFunctional Genomics and Proteomics Group, Department of Biology, KU Leuven, 3000 Leuven, Belgium.ORCID 0000-0001-7887-6967
Olivier MirabeauGenetics and Biology of Cancers Unit, Institut Curie, INSERM U830, Paris Sciences et Lettres Research University, Paris 75005, France.
Geert DepuydtFunctional Genomics and Proteomics Group, Department of Biology, KU Leuven, 3000 Leuven, Belgium.
Matthias Boris Van HielFunctional Genomics and Proteomics Group, Department of Biology, KU Leuven, 3000 Leuven, Belgium.
Katleen PeymenFunctional Genomics and Proteomics Group, Department of Biology, KU Leuven, 3000 Leuven, Belgium.
Jan WatteyneFunctional Genomics and Proteomics Group, Department of Biology, KU Leuven, 3000 Leuven, Belgium.
Sven ZelsFunctional Genomics and Proteomics Group, Department of Biology, KU Leuven, 3000 Leuven, Belgium.
Liliane SchoofsFunctional Genomics and Proteomics Group, Department of Biology, KU Leuven, 3000 Leuven, Belgium; liliane.schoofs@kuleuven.be isabel.beets@kuleuven.be.
Isabel BeetsFunctional Genomics and Proteomics Group, Department of Biology, KU Leuven, 3000 Leuven, Belgium; liliane.schoofs@kuleuven.be isabel.beets@kuleuven.be.
KU Leuven · BEInserm · FR

Funding

Enhancing and expanding the CGC Strain CollectionP40OD010440 · OD · UNIVERSITY OF MINNESOTA · PI Aric L Daul, Ann E. Rougvie · 2012 to 2026
$7.5M
NIH HHS P40 OD010440
6 · The paper itself

Abstract

In vertebrates thyrotropin-releasing hormone (TRH) is a highly conserved neuropeptide that exerts the hormonal control of thyroid-stimulating hormone (TSH) levels as well as neuromodulatory functions. However, a functional equivalent in protostomian animals remains unknown, although TRH receptors are conserved in proto- and deuterostomians. Here we identify a TRH-like neuropeptide precursor in

Indexed as

Amino Acid SequenceAnimalsBody SizeCaenorhabditis elegansConserved SequenceCRISPR-Cas SystemsDietEvolution, MolecularGastrointestinal MotilityReceptors, Thyrotropin-Releasing HormoneRNA InterferenceThyrotropin-Releasing HormoneTransforming Growth Factor betaReceptors, Thyrotropin-Releasing HormoneThyrotropin-Releasing HormoneTransforming Growth Factor betaC. elegansgrowth regulationmolecular evolutionneuropeptidethyrotropin-releasing hormone

Identifiers

PMID28461507
PMCPMC5441806
OpenAlexW2611563424

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.