ArticleProceedings of the National Academy of Sciences of the United States of America2017
Variation in the β-endorphin, oxytocin, and dopamine receptor genes is associated with different dimensions of human sociality.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 60 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
60 citing papers in PubMed.
- Application of Affective Touch in Patients With Advanced Cancer: Effects on Existential Distress, Pain, and Quality of Life.The journal of nursing research : JNR · 2026Trial
- Blocking mu-opioid receptors inhibits social bonding in rituals.Biology letters · 2020Trial
- Explainable drug side effect prediction in central neural system via biologically informed graph neural network.Translational psychiatry · 2026Article
- Beyond distress relief: the Anhedonic Subtype of nonsuicidal self-injury and the imperative for Positive Affect Treatment.Frontiers in psychiatry · 2026Article
- Oxytocin and opioid antagonists: A dual approach to improving social behavior.Annals of the New York Academy of Sciences · 2025Review
- Relating Biopsychosocial Meanings to Semi-Quantitative CRP Readings Among Primary Healthcare Users: Trends from a Cross-Sectional Study Analysis.Journal of clinical medicine · 2025Article
- Why friendship and loneliness affect our health.Annals of the New York Academy of Sciences · 2025Review
- Identity change and the transition to university: Implications for cortisol awakening response, psychological well-being and academic performance.Applied psychology. Health and well-being · 2025Article
- Effects of physical activity on college students' interpersonal competence: chain-mediated effects of self-control and prosocial interpersonal emotional management.Frontiers in psychology · 2025Article
- Music as a social instrument: a brief historical and conceptual perspective.Frontiers in cognition · 2025Review
- Genetic variations as predictors of dispositional and dyadic empathy-a couple study.Scientific reports · 2024Article
- Joint Roles of Oxytocin- and Dopamine-Related Genes and Childhood Parenting Experience in Maternal Supportive Social Network.Child psychiatry and human development · 2024Article
- Whole-Body Photobiomodulation Therapy Propels the Fibromyalgia Patient into the Recomposition Phase: A Reflexive Thematic Analysis.Biomedicines · 2024Article
- Love songs and serenades: a theoretical review of music and romantic relationships.Frontiers in psychology · 2024Article
- Article
- Only empathy-related traits, not being mimicked or endorphin release, influence social closeness and prosocial behavior.Scientific reports · 2023Article
- Molecular and cellular evolution of the amygdala across species analyzed by single-nucleus transcriptome profiling.Cell discovery · 2023Article
- The origins and function of musical performance.Frontiers in psychology · 2023Article
- Why did doctrinal religions first appear in the Northern Subtropical Zone?Evolutionary human sciences · 2023Review
- Genetic and epigenetic effects on couple adjustment in context of romantic relationship: A scoping systematic review.Frontiers in genetics · 2023Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
There is growing evidence that the number and quality of social relationships have substantial impacts on health, well-being, and longevity, and, at least in animals, on reproductive fitness. Although it is widely recognized that these outcomes are mediated by a number of neuropeptides, the roles these play remain debated. We suggest that an overemphasis on one neuropeptide (oxytocin), combined with a failure to distinguish between different social domains, has obscured the complexity involved. We use variation in 33 SNPs for the receptor genes for six well-known social neuropeptides in relation to three separate domains of sociality (social disposition, dyadic relationships, and social networks) to show that three neuropeptides (β-endorphin, oxytocin, and dopamine) play particularly important roles, with each being associated predominantly with a different social domain. However, endorphins and dopamine have a much wider compass than oxytocin (whose effects are confined to romantic/reproductive relationships and often do not survive control for other neuropeptides). In contrast, vasopressin, serotonin, and testosterone play only limited roles.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.