Evidence map›Paper›PMID 28461337›Full record

ArticleThe Journal of biological chemistry2017

The mitochondrial outer membrane protein mitoNEET is a redox enzyme catalyzing electron transfer from FMNH

Yiming Wang, Aaron P Landry, Huangen Ding

Open access · hybridAbstract readComparative Study
In one paragraph

Article in The Journal of biological chemistry, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.

0numbers the graph read from it
0cells of the map it votes in
41citing papers in PubMed
2.4field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

41 citing papers in PubMed, 70 citations in OpenAlex.

  1. Review
  2. Regulation of mitochondrial iron homeostasis in tumor cells.Molecular medicine (Cambridge, Mass.) · 2026
    Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Review
  8. Pulling back the mitochondria's iron curtain.npj metabolic health and disease · 2025
    Review
  9. Redox report : communications in free radical research · 2024
    Article
  10. Iron regulates the quiescence of naive CD4 T cells by controlling mitochondria and cellular metabolism.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  11. PINK1 and Parkin regulate IPNature communications · 2023
    Article
  12. Article
  13. Review
  14. Rejuvenation: Turning Back Time by Enhancing CISD2.International journal of molecular sciences · 2022
    Review
  15. Article
  16. Article
  17. Article
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Yiming WangFrom the Department of Biological Sciences, Louisiana State University, Baton Rouge, Louisiana 70803.
Aaron P LandryFrom the Department of Biological Sciences, Louisiana State University, Baton Rouge, Louisiana 70803.
Huangen DingFrom the Department of Biological Sciences, Louisiana State University, Baton Rouge, Louisiana 70803 hding@lsu.edu.ORCID 0000-0002-4815-7336
Louisiana State University · US

Funding

Modification of human mitoNEET [2Fe-2S] cluster under nitric oxide stressR15GM109399 · NIGMS · LOUISIANA STATE UNIV A&M COL BATON ROUGE · PI DING, HUANGEN · 2014 to 2014
$336k
NIGMS NIH HHS R15 GM109399
6 · The paper itself

Abstract

Increasing evidence suggests that mitoNEET, a target of the type II diabetes drug pioglitazone, is a key regulator of energy metabolism in mitochondria. MitoNEET is anchored to the mitochondrial outer membrane via its N-terminal α helix domain and hosts a redox-active [2Fe-2S] cluster in its C-terminal cytosolic region. The mechanism by which mitoNEET regulates energy metabolism in mitochondria, however, is not fully understood. Previous studies have shown that mitoNEET specifically interacts with the reduced flavin mononucleotide (FMNH

Indexed as

Electron Spin Resonance SpectroscopyElectron TransportEnergy MetabolismEscherichia coli ProteinsFlavin MononucleotideFMN ReductaseHumansHydroquinonesHypoglycemic AgentsKineticsMitochondrial MembranesMitochondrial ProteinsOxidation-ReductionPeptide FragmentsPioglitazoneRecombinant Proteins5-(3,5-di-tert-butyl-4-hydroxybenzyl)-4-hydroxythiazol-2(5H)-oneCISD1 protein, humanEscherichia coli ProteinsFlavin Mononucleotideflavin mononucleotide hydroquinoneFMN ReductaseFre protein, E coliHydroquinonesHypoglycemic AgentsMitochondrial ProteinsPeptide FragmentsPioglitazoneRecombinant ProteinsThiazolesThiazolidinedionesUbiquinoneUbiquinone Q2electron paramagnetic resonance (EPR)electron transferFMNiron-sulfur proteintype 2 diabetes

Identifiers

PMID28461337
PMCPMC5473213
OpenAlexW2611332402

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.