Evidence map›Paper›PMID 28461336›Full record

ArticleThe Journal of biological chemistry2017

Ets homologous factor (EHF) has critical roles in epithelial dysfunction in airway disease.

Sara L Fossum, Michael J Mutolo, Antonio Tugores, Sujana Ghosh, Scott H Randell, Lisa C Jones, Shih-Hsing Leir, Ann Harris

Open access · hybridAbstract read
In one paragraph

Article in The Journal of biological chemistry, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.

0numbers the graph read from it
0cells of the map it votes in
44citing papers in PubMed
5.3field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

44 citing papers in PubMed, 60 citations in OpenAlex.

  1. Article
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  8. Cellular imbalance in proximal and distal lung of CFTRMolecular medicine (Cambridge, Mass.) · 2025
    Article
  9. Article
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  11. Notch2 Inhibition and Kidney Cyst Growth in Autosomal Dominant Polycystic Kidney Disease.Journal of the American Society of Nephrology : JASN · 2025
    Article
  12. Cpeb4-mediated Dclk2 promotes neuronal pyroptosis induced by chronic cerebral ischemia through phosphorylation of Ehf.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2024
    Article
  13. Review
  14. Tissue-Specific Regulation ofInternational journal of molecular sciences · 2023
    Review
  15. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 2 countries.

Sara L FossumFrom the Human Molecular Genetics Program, Lurie Children's Research Center, Chicago, Illinois 60614.
Michael J MutoloFrom the Human Molecular Genetics Program, Lurie Children's Research Center, Chicago, Illinois 60614.
Antonio Tugoresthe Unidad de Investigación, Complejo Hospitalario Universitario Insular Materno Infantil, 35016 Las Palmas de Gran Canaria, Spain.
Sujana GhoshFrom the Human Molecular Genetics Program, Lurie Children's Research Center, Chicago, Illinois 60614.
Scott H Randellthe Marsico Lung Institute, University of North Carolina Cystic Fibrosis Center, University of North Carolina, Chapel Hill, North Carolina 27599, and.
Lisa C Jonesthe Marsico Lung Institute, University of North Carolina Cystic Fibrosis Center, University of North Carolina, Chapel Hill, North Carolina 27599, and.
Shih-Hsing LeirFrom the Human Molecular Genetics Program, Lurie Children's Research Center, Chicago, Illinois 60614.
Ann HarrisFrom the Human Molecular Genetics Program, Lurie Children's Research Center, Chicago, Illinois 60614, ann.harris@case.edu.
Northwestern University · USHospital Universitario Insular de Gran Canaria · ESLung Institute · USUniversity of North Carolina at Chapel Hill · US

Funding

Vector CoreP30DK065988 · NIDDK · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Richard Charles Boucher, Martina Gentzsch · 2004 to 2026
$26.5M
CELLULAR &MOLECULAR BASIS OF DISEASE TRAINING PROGRAMT32GM008061 · NIGMS · NORTHWESTERN UNIVERSITY · PI CARTHEW, RICHARD W. · 1985 to 2022
$17.1M
Tissue-specific regulation of a gene essential for normal airway epitheliaR01HL094585 · NHLBI · LURIE CHILDREN'S HOSPITAL OF CHICAGO · PI HARRIS, ANN · 2009 to 2020
$2.9M
Mining open chromatin to define molecular mechanisms of CF modifier genesR01HL117843 · NHLBI · LURIE CHILDREN'S HOSPITAL OF CHICAGO · PI HARRIS, ANN, KNOWLES, MICHAEL R · 2013 to 2017
$2.9M
Transcriptional Networks Regulating Luminal Environment in the EpididymisR01HD068901 · NICHD · LURIE CHILDREN'S HOSPITAL OF CHICAGO · PI HARRIS, ANN · 2011 to 2023
$2.8M
The Role of the EHF Transcription Factor in Lung Epithelial FunctionF30HL124925 · NHLBI · LURIE CHILDREN'S HOSPITAL OF CHICAGO · PI FOSSUM, SARA · 2015 to 2016
$85k
A novel microRNA in pulmonary fibrosisF31HL126458 · NHLBI · LURIE CHILDREN'S HOSPITAL OF CHICAGO · PI STOLZENBURG, LINDSAY · 2015 to 2016
$72k
NHLBI NIH HHS F30 HL124925NHLBI NIH HHS F31 HL126458NHLBI NIH HHS R01 HL094585NHLBI NIH HHS R01 HL117843NICHD NIH HHS R01 HD068901NIDDK NIH HHS P30 DK065988NIGMS NIH HHS T32 GM008061
6 · The paper itself

Abstract

The airway epithelium forms a barrier between the internal and external environments. Epithelial dysfunction is critical in the pathology of many respiratory diseases, including cystic fibrosis. Ets homologous factor (EHF) is a key member of the transcription factor network that regulates gene expression in the airway epithelium in response to endogenous and exogenous stimuli.

Indexed as

BronchiCell LineChemokinesCystic FibrosisEpithelial CellsGoblet CellsHumansHyperplasiaNeutrophilsTranscription FactorsChemokinesEHF protein, humanTranscription FactorsChIP sequencing (ChIP-seq)epitheliumEts homologous factor (EHF)ETS transcription factor familylung injurysiRNAtranscription factortranscriptomics

Identifiers

PMID28461336
PMCPMC5491778
OpenAlexW2611456245

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.