Evidence map›Paper›PMID 28461314›Full record

ArticleAntimicrobial agents and chemotherapy2017

NDM-5 and OXA-181 Beta-Lactamases, a Significant Threat Continues To Spread in the Americas.

Laura J Rojas, Andrea M Hujer, Susan D Rudin, Meredith S Wright, T Nicholas Domitrovic, Steven H Marshall, Kristine M Hujer, Sandra S Richter, Eric Cober, Federico Perez and 3 more

Open access · bronzeAbstract read
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
54citing papers in PubMed, 1 pooled it
2.9field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

54 citing papers in PubMed, 1 synthesis or guideline pooled it, 77 citations in OpenAlex.

  1. Systematic review of multidrug-resistantFrontiers in microbiology · 2025
    Pooled it
  2. Phase I trial to evaluate safety of Deferiprone-Chitogel to prevent epidural fibrosis in lumbar spine surgery.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2026
    Article
  3. Genomic characterization ofFrontiers in microbiology · 2026
    Article
  4. Identification of Potential Inhibitors of Three NDM Variants ofCurrent computer-aided drug design · 2025
    Article
  5. Article
  6. Emergence ofAntibiotics (Basel, Switzerland) · 2024
    Article
  7. Article
  8. Article
  9. Microbiology spectrum · 2024
    Article
  10. Microbiology spectrum · 2024
    Article
  11. Article
  12. Article
  13. Article
  14. Review
  15. Diversity and Distribution ofAntibiotics (Basel, Switzerland) · 2023
    Article
  16. Article
  17. Article
  18. Article
  19. The First Report ofInfection and drug resistance · 2023
    Article
  20. Characterization of NDM-5 Carbapenemase-Encoding Gene (Infection and drug resistance · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 6 institutions in 1 country.

Laura J RojasResearch Service, Louis Stokes Cleveland Department of Veterans Affairs Medical Center, Cleveland, Ohio, USA.
Andrea M HujerResearch Service, Louis Stokes Cleveland Department of Veterans Affairs Medical Center, Cleveland, Ohio, USA.
Susan D RudinResearch Service, Louis Stokes Cleveland Department of Veterans Affairs Medical Center, Cleveland, Ohio, USA.
Meredith S WrightJ. Craig Venter Institute, La Jolla, California, USA.
T Nicholas DomitrovicResearch Service, Louis Stokes Cleveland Department of Veterans Affairs Medical Center, Cleveland, Ohio, USA.
Steven H MarshallResearch Service, Louis Stokes Cleveland Department of Veterans Affairs Medical Center, Cleveland, Ohio, USA.
Kristine M HujerResearch Service, Louis Stokes Cleveland Department of Veterans Affairs Medical Center, Cleveland, Ohio, USA.
Sandra S RichterDepartment of Laboratory Medicine, Cleveland Clinic, Cleveland, Ohio, USA.
Eric CoberDepartment of Infectious Diseases, Cleveland Clinic, Cleveland, Ohio, USA.
Federico PerezMedical Service, Louis Stokes Cleveland Department of Veterans Affairs Medical Center, Cleveland, Ohio, USA.
Mark D AdamsJ. Craig Venter Institute, La Jolla, California, USA.
David van DuinDivision of Infectious Diseases, University of North Carolina, Chapel Hill, North Carolina, USA david_vanduin@med.unc.edu robert.bonomo@va.gov.
Robert A BonomoMedical Service, Louis Stokes Cleveland Department of Veterans Affairs Medical Center, Cleveland, Ohio, USA david_vanduin@med.unc.edu robert.bonomo@va.gov.
Louis Stokes Cleveland VA Medical Center · USCleveland Clinic · USJ. Craig Venter Institute · USUniversity School · USCase Western Reserve University · USUniversity of North Carolina at Chapel Hill · US

Funding

Antibacterial Resistance Leadership Group (ARLG)UM1AI104681 · NIAID · DUKE UNIVERSITY · PI Vance G. Fowler, Henry F HENRY CHAMBERS · 2013 to 2026
$180.8M
Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
Clinical and Translational Science Collaborative of ClevelandUL1TR000439 · NCATS · CASE WESTERN RESERVE UNIVERSITY · PI KONSTAN, MICHAEL W. · 2012 to 2016
$50.0M
The J. Craig Venter Institute Genome Center for Infectious DiseasesU19AI110819 · NIAID · J. CRAIG VENTER INSTITUTE, INC. · PI TAN, GENE · 2014 to 2018
$29.7M
Understanding B-Lactam Resistance in Acinetobacter baumanniiR01AI072219 · NIAID · CASE WESTERN RESERVE UNIVERSITY · PI ROBERT A. BONOMO, Philip N. Rather · 2007 to 2026
$6.6M
Understanding ceftazidime resistance in SHV B-LactamasesR01AI063517 · NIAID · CASE WESTERN RESERVE UNIVERSITY · PI BONOMO, ROBERT A. · 2005 to 2023
$4.9M
A Mechanism-Based Approach to Metallo-beta-Lactamase InhibitionR01AI100560 · NIAID · CASE WESTERN RESERVE UNIVERSITY · PI BONOMO, ROBERT A., SPENCER, JAMES · 2012 to 2022
$4.4M
Molecular Epidemiology of Carbapenem-Resistant Klebsiella pneumoniaeR21AI114508 · NIAID · CASE WESTERN RESERVE UNIVERSITY · PI BONOMO, ROBERT A., VAN DUIN, DAVID · 2015 to 2016
$445k
The Continuing Challenge of Carbapenemases in K. pneumoniae: KPC-2 & NDM-1I01BX001974 · VA · LOUIS STOKES CLEVELAND VA MEDICAL CENTER · PI BONOMO, ROBERT A. · 2013 to 2024
–
BLRD VA I01 BX001974NCATS NIH HHS UL1 TR000439NCATS NIH HHS UL1 TR001863NIAID NIH HHS R01 AI063517NIAID NIH HHS R01 AI072219NIAID NIH HHS R01 AI100560NIAID NIH HHS R21 AI114508NIAID NIH HHS U19 AI110819NIAID NIH HHS UM1 AI104681
6 · The paper itself

Abstract

Among Gram-negative bacteria, carbapenem-resistant infections pose a serious and life-threatening challenge. Here, the CRACKLE network reports a sentinel detection and characterization of a carbapenem-resistant

Indexed as

Anti-Bacterial Agentsbeta-LactamasesCarbapenemsHumansIndiaKlebsiella InfectionsKlebsiella pneumoniaeMaleMicrobial Sensitivity TestsPlasmidsAnti-Bacterial Agentsbeta-LactamasesCarbapenemsKlebsiella pneumoniaeNDM-5OXA-181

Identifiers

PMID28461314
PMCPMC5487671
OpenAlexW2610356195

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.