SynthesisThe European respiratory journal2017
A meta-analysis of genome-wide association studies of asthma in Puerto Ricans.
Open access · bronzeAbstract readMeta-Analysis
In one paragraph
Synthesis in The European respiratory journal, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 3 of them syntheses that pooled it.
0numbers the graph read from it
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36citing papers in PubMed, 3 pooled it
5.4field-weighted citation impact, top 4% of its field
What it found
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Who cites it
36 citing papers in PubMed, 3 syntheses or guidelines pooled it, 62 citations in OpenAlex.
- Genome-wide association study in minority children with asthma implicates DNAH5 in bronchodilator responsiveness.Scientific reports · 2022Pooled it
- A genome-wide association study of severe asthma exacerbations in Latino children and adolescents.The European respiratory journal · 2021Pooled it
- Association study in African-admixed populations across the Americas recapitulates asthma risk loci in non-African populations.Nature communications · 2019Pooled it
- Estimating in silico causal effects of DNA methylation on gene expression through genetic anchors in airway epithelium in asthma.Science advances · 2026Article
- Sequencing and health data resource of children of African ancestry.Genetics in medicine : official journal of the American College of Medical Genetics · 2026Article
- Gene Polymorphisms Associated with Treatment Response of Asthma in Chinese Children.Journal of asthma and allergy · 2026Article
- Association of 17q12-q21 Asthma Risk Locus with Clinical Severity of Infant Respiratory Syncytial Virus Infection.Biomolecules · 2025Article
- Parent-of-Origin Effects in Childhood Asthma at Seven Years of Age.Genetic epidemiology · 2025Article
- Advancements in genetic research by the Hispanic Community Health Study/Study of Latinos: A 10-year retrospective review.HGG advances · 2025Review
- MOSES: a methylation-based gene association approach for unveiling environmentally regulated genes linked to a trait or disease.Clinical epigenetics · 2024Article
- Genetics of chronic respiratory disease.Nature reviews. Genetics · 2024Review
- Association between bronchial asthma and TSLP gene polymorphism: a systematic review and meta-analysis.Annals of medicine and surgery (2012) · 2024Review
- Unspecified asthma, childhood-onset, and adult-onset asthma have different causal genes: a Mendelian randomization analysis.Frontiers in immunology · 2024Article
- Genetic risk prediction in Hispanics/Latinos: milestones, challenges, and social-ethical considerations.Journal of community genetics · 2023Review
- Cis- and trans-eQTM analysis reveals novel epigenetic and transcriptomic immune markers of atopic asthma in airway epithelium.The Journal of allergy and clinical immunology · 2023Article
- From gene identifications to therapeutic targets for asthma: Focus on great potentials ofChinese medical journal pulmonary and critical care medicine · 2023Review
- Association of childhood asthma with Gasdermin B (GSDMB) and Oromucoid-like 3 (ORMDL3) genes.Northern clinics of Istanbul · 2023Article
- Article
- Genome-wide association study of asthma, total IgE, and lung function in a cohort of Peruvian children.The Journal of allergy and clinical immunology · 2021Article
- Lymph node-resident dendritic cells drive TScience immunology · 2021Article
Corrections and comments
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Authors and funding
23 authors at 9 institutions in 3 countries.
Qi YanDivision of Pediatric Pulmonary Medicine, Allergy, and Immunology, Children's Hospital of Pittsburgh of UPMC, University of Pittsburgh, Pittsburgh, PA, USA.
John BrehmDivision of Pediatric Pulmonary Medicine, Allergy, and Immunology, Children's Hospital of Pittsburgh of UPMC, University of Pittsburgh, Pittsburgh, PA, USA.
Maria Pino-YanesCIBER de Enfermedades Respiratorias, Instituto de Salud Carlos III, Madrid, Spain.
Erick FornoDivision of Pediatric Pulmonary Medicine, Allergy, and Immunology, Children's Hospital of Pittsburgh of UPMC, University of Pittsburgh, Pittsburgh, PA, USA.ORCID 0000-0001-6497-9885
Jerome LinDept of Human Genetics, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA.
Sam S OhDept of Medicine, University of California San Francisco, San Francisco, CA, USA.
Edna Acosta-PerezBehavioral Sciences Research Institute, University of Puerto Rico, San Juan, Puerto Rico.
Cathy C LaurieDept of Biostatistics, University of Washington, Seattle, WA, USA.
Michelle M CloutierDept of Pediatrics, University of Connecticut, Farmington, CT, USA.
Benjamin A RabyChanning Division of Network Medicine, Dept of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Adrienne M StilpDept of Biostatistics, University of Washington, Seattle, WA, USA.
Tamar SoferDept of Biostatistics, University of Washington, Seattle, WA, USA.
Donglei HuDept of Medicine, University of California San Francisco, San Francisco, CA, USA.
Scott HuntsmanDept of Medicine, University of California San Francisco, San Francisco, CA, USA.
Celeste S EngDept of Medicine, University of California San Francisco, San Francisco, CA, USA.
Matthew P ConomosDept of Biostatistics, University of Washington, Seattle, WA, USA.
Deepa RastogiDept of Pediatrics, Albert Einstein College of Medicine, Bronx, NY, USA.
Kenneth RiceDept of Biostatistics, University of Washington, Seattle, WA, USA.
Glorisa CaninoBehavioral Sciences Research Institute, University of Puerto Rico, San Juan, Puerto Rico.
Wei ChenDivision of Pediatric Pulmonary Medicine, Allergy, and Immunology, Children's Hospital of Pittsburgh of UPMC, University of Pittsburgh, Pittsburgh, PA, USA.
R Graham BarrDept of Epidemiology, Columbia University, New York, NY, USA.
Esteban G BurchardDept of Medicine, University of California San Francisco, San Francisco, CA, USA.
Juan C CeledónDivision of Pediatric Pulmonary Medicine, Allergy, and Immunology, Children's Hospital of Pittsburgh of UPMC, University of Pittsburgh, Pittsburgh, PA, USA juan.celedon@chp.edu.
University of Pittsburgh · USUniversity of California, San Francisco · USUniversity of Washington · USUniversity of Puerto Rico System · PRAlbert Einstein College of Medicine · USBrigham and Women's Hospital · USColumbia University · USUniversidad de La Laguna · ESUniversity of Connecticut · US
Funding
The Airway Functional Genomics of Bronchodilator Drug Response in Minority Children with AsthmaR01HL117004 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI AHITUV, NADAV, SEIBOLD, MAX A · 2013 to 2022
$9.3MCLINICAL, PHARMACOLOGY, DRUG ACTION &PHARMACOKINETICST32GM007546 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Radojka Savic · 1985 to 2026
$8.9MSocial Interventions to address disparities In young adult tobacco useP60MD006902 · NIMHD · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI HIATT, ROBERT A · 2012 to 2016
$6.4MEpigenetic Variation and Childhood Asthma in Puerto RicansR01HL117191 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI CELEDON, JUAN CARLOS · 2013 to 2020
$5.8MGene-environments and Admixture in Latino Asthmatics (GALA 2)R01ES015794 · NIEHS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI BURCHARD, ESTEBAN GONZALEZ · 2008 to 2012
$5.4MWhole Genome Analyses for Asthma in Latino PopulationsR01HL088133 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI BURCHARD, ESTEBAN GONZALEZ · 2008 to 2012
$3.8MGenes, Home Allergens and Asthma Puerto Rican ChildrenR01HL079966 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI CELEDON, JUAN CARLOS · 2006 to 2010
$3.8MThalassemia Clinical Research Network, CanadaU01HL065233 · NHLBI · UNIVERSITY HEALTH NETWORK · PI OLIVIERI, NANCY F · 2000 to 2009
$2.6MGENETIC ARCHITECTURE OF PLASMA T-PA AND PAI-1R01HL065234 · NHLBI · VANDERBILT UNIVERSITY · PI MOORE, JASON H. · 2000 to 2004
$1.7MGenetic and Epigenetic Determinants of Pediatric Obesity-Associated AsthmaK23HL118733 · NHLBI · CHILDREN'S RESEARCH INSTITUTE · PI RASTOGI, DEEPA · 2014 to 2018
$893kGenetics of Asthma In Latino AmericansK23HL004464 · NHLBI · UNIVERSITY OF CALIFORNIA SAN FRANCISCO · PI BURCHARD, ESTEBAN GONZALEZ · 2001 to 2005
$609kObesity and Asthma Subphenotypes and Underlying Genetic and Genomic PathwaysK08HL125666 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI FORNO, ERICK · 2015 to 2018
$589kNHLBI NIH HHS HHSN268201300005CNHLBI NIH HHS K08 HL125666NHLBI NIH HHS K23 HL004464NHLBI NIH HHS K23 HL118733NHLBI NIH HHS N01 HC065233NHLBI NIH HHS N01 HC065234NHLBI NIH HHS N01 HC065235NHLBI NIH HHS N01 HC065236NHLBI NIH HHS N01 HC065237NHLBI NIH HHS R01 HL079966NHLBI NIH HHS R01 HL088133NHLBI NIH HHS R01 HL117004NHLBI NIH HHS R01 HL117191NIEHS NIH HHS R01 ES015794NIEHS NIH HHS R21 ES024844NIGMS NIH HHS T32 GM007546NIMHD NIH HHS P60 MD006902
Abstract
Puerto Ricans are disproportionately affected with asthma in the USA. In this study, we aim to identify genetic variants that confer susceptibility to asthma in Puerto Ricans.We conducted a meta-analysis of genome-wide association studies (GWAS) of asthma in Puerto Ricans, including participants from: the Genetics of Asthma in Latino Americans (GALA) I-II, the Hartford-Puerto Rico Study and the Hispanic Community Health Study. Moreover, we examined whether susceptibility loci identified in previous meta-analyses of GWAS are associated with asthma in Puerto Ricans.The only locus to achieve genome-wide significance was chromosome 17q21, as evidenced by our top single nucleotide polymorphism (SNP), rs907092 (OR 0.71, p=1.2×10
Indexed as
Genome-Wide Association StudyPolymorphism, Single NucleotideAdolescentAdultAsthmaChildChromosomes, Human, Pair 17FemaleGenetic Predisposition to DiseaseHispanic or LatinoHumansLinkage DisequilibriumLogistic ModelsMaleMiddle AgedPuerto Rico
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