Evidence map›Paper›PMID 28461248›Full record

ArticleNeurobiology of disease2017

Simultaneous triple therapy for the treatment of status epilepticus.

Jerome Niquet, Roger Baldwin, Keith Norman, Lucie Suchomelova, Lucille Lumley, Claude G Wasterlain

Open access · greenAbstract read
In one paragraph

Article in Neurobiology of disease, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed, 1 pooled it
2.5field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 1 synthesis or guideline pooled it, 52 citations in OpenAlex.

  1. Pooled it
  2. Perampanel as a candidate for polytherapy in Stage 1 Plus status epilepticus: biological rationale and translational limits.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2026
    Review
  3. Article
  4. Review
  5. Pathophysiology of Status Epilepticus Revisited.International journal of molecular sciences · 2025
    Review
  6. Review
  7. Review
  8. Review
  9. Article
  10. Article
  11. Article
  12. Article
  13. Review
  14. Review
  15. Article
  16. Article
  17. Deregulation of Astroglial TASK-1 KInternational journal of molecular sciences · 2023
    Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Jerome NiquetDepartment of Neurology, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA; Epilepsy Research Laboratory (151), Veterans Affairs Greater Los Angeles Healthcare System, Los Angeles, CA, USA. Electronic address: jniquet@ucla.edu.
Roger BaldwinEpilepsy Research Laboratory (151), Veterans Affairs Greater Los Angeles Healthcare System, Los Angeles, CA, USA.
Keith NormanEpilepsy Research Laboratory (151), Veterans Affairs Greater Los Angeles Healthcare System, Los Angeles, CA, USA.
Lucie SuchomelovaEpilepsy Research Laboratory (151), Veterans Affairs Greater Los Angeles Healthcare System, Los Angeles, CA, USA.
Lucille LumleyUS Army Medical Research Institute of Chemical Defense (USAMRICD), 2900 Ricketts Point Rd., Aberdeen Proving Ground, MD 21010, USA.
Claude G WasterlainDepartment of Neurology, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA; Epilepsy Research Laboratory (151), Veterans Affairs Greater Los Angeles Healthcare System, Los Angeles, CA, USA; Brain Research Institute, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.
VA Greater Los Angeles Healthcare System · USUniversity of California, Los Angeles · US

Funding

Rational polytherapy in the treatment of cholinergic seizuresU01NS074926 · NINDS · BRENTWOOD BIOMEDICAL RESEARCH INSTITUTE · PI WASTERLAIN, CLAUDE G · 2011 to 2015
$3.3M
Treatment of Status Epilepticus: A Translational ProposalI01BX000273 · VA · VA GREATER LOS ANGELES HEALTHCARE SYSTEM · PI WASTERLAIN, CLAUDE G · 2009 to 2017
–
BLRD VA I01 BX000273NINDS NIH HHS U01 NS074926
6 · The paper itself

Abstract

Early maladaptive internalization of synaptic GABA

Indexed as

AnimalsAnticonvulsantsBrain WavesCombined Modality TherapyDisease Models, AnimalDose-Response Relationship, DrugDrug Therapy, CombinationElectroencephalographyMaleMaze LearningMidazolamNeuronsPhenytoinPilocarpineRatsRats, Sprague-DawleyAnticonvulsantsfosphenytoinMidazolamPhenytoinPilocarpineValproic AcidCholinergic seizuresKetamineMidazolamRefractory status epilepticusValproate

Identifiers

PMID28461248
PMCPMC5504687
OpenAlexW2609553079

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.