ArticleDevelopmental biology2017
PHRED-1 is a divergent neurexin-1 homolog that organizes muscle fibers and patterns organs during regeneration.
Article in Developmental biology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
11 citing papers in PubMed, 17 citations in OpenAlex.
- Transcription Factors Active in the Anterior Blastema ofBiomolecules · 2021Article
- Decoding Stem Cells: An Overview on Planarian Stem Cell Heterogeneity and Lineage Progression.Biomolecules · 2021Review
- Identification of rare, transient post-mitotic cell states that are induced by injury and required for whole-body regeneration in Schmidtea mediterranea.Nature cell biology · 2021Article
- Planarian stem cells sense the identity of the missing pharynx to launch its targeted regeneration.eLife · 2021Article
- Article
- Regulation of Genomic Output and (Pluri)potency in Regeneration.Annual review of genetics · 2019Review
- Muscle functions as a connective tissue and source of extracellular matrix in planarians.Nature communications · 2019Article
- Regenerative tissue remodeling in planarians - The mysteries of morphallaxis.Seminars in cell & developmental biology · 2019Review
- Biophysical and structural characterization of the thermostable WD40 domain of a prokaryotic protein, Thermomonospora curvata PkwA.Scientific reports · 2018Article
- Chemical Amputation and Regeneration of the Pharynx in the Planarian Schmidtea mediterranea.Journal of visualized experiments : JoVE · 2018Article
- Article
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
Regeneration of body parts requires the replacement of multiple cell types. To dissect this complex process, we utilized planarian flatworms that are capable of regenerating any tissue after amputation. An RNAi screen for genes involved in regeneration of the pharynx identified a novel gene, Pharynx regeneration defective-1 (PHRED-1) as essential for normal pharynx regeneration. PHRED-1 is a predicted transmembrane protein containing EGF, Laminin G, and WD40 domains, is expressed in muscle, and has predicted homologs restricted to other lophotrochozoan species. Knockdown of PHRED-1 causes abnormal regeneration of muscle fibers in both the pharynx and body wall muscle. In addition to defects in muscle regeneration, knockdown of PHRED-1 or the bHLH transcription factor MyoD also causes defects in muscle and intestinal regeneration. Together, our data demonstrate that muscle plays a key role in restoring the structural integrity of closely associated organs, and in planarians it may form a scaffold that facilitates normal intestinal branching.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.