Evidence map›Paper›PMID 28461132›Full record

ArticleMagnetic resonance imaging2017

A non-contrast CMR index for assessing myocardial fibrosis.

Qian Yin, Dana Abendschein, David Muccigrosso, Robert O'Connor, Thomas Goldstein, Ridong Chen, Jie Zheng

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Magnetic resonance imaging, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
0.2field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 25 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Article
  5. Free-breathing simultaneous native myocardial T1, T2 and T1ρ mapping with Cartesian acquisition and dictionary matching.Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance · 2023
    Article
  6. Magnetic resonance myocardial T1ρ mapping : Technical overview, challenges, emerging developments, and clinical applications.Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance · 2023
    Review
  7. Quantification correction for free-breathing myocardial TJournal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance · 2022
    Article
  8. Fast myocardial TMagma (New York, N.Y.) · 2022
    Article
  9. Review
  10. Endogenous T1ρ cardiovascular magnetic resonance in hypertrophic cardiomyopathy.Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance · 2021
    Article
  11. Article
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 5 institutions in 2 countries.

Qian YinMallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, MO, USA; Department of Radiology, Tangdu Hospital, Xi'an, Shaanxi Province, China.
Dana AbendscheinCenter for Cardiovascular Research, Department of Medicine, Washington University School of Medicine, St. Louis, MO, USA.
David MuccigrossoMallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, MO, USA.
Robert O'ConnorNIDDK, National Institutes of Health, Bethesda, MD, USA.
Thomas GoldsteinDepartment of Computer Science, University of Maryland, College Park, MD, USA.
Ridong ChenAPT Therapeutics Inc., 4041 Forest Park Avenue, St. Louis, MO, USA.
Jie ZhengMallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, MO, USA. Electronic address: zhengj@mir.wustl.edu.
Mallinckrodt (United States) · USAPT Therapeutics (United States) · USNational Institutes of Health · USUniversity of Maryland, College Park · USWashington University in St. Louis · US

Funding

NMR Facility Management and Application Of NMR SpectroscopyZIADK032101 · NIDDK · NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES · PI BEWLEY, CAROLE · 2009 to 2025
$4.9M
Adjunctive Use of Apyrase to Fibrinolytic TherapyR44HL095169 · NHLBI · APT THERAPEUTICS, INC. · PI CHEN, RIDONG · 2012 to 2013
$1.3M
NHLBI NIH HHS R44 HL095169
6 · The paper itself

Abstract

purposeSafe, sensitive, and non-invasive imaging methods to assess the presence, extent, and turnover of myocardial fibrosis are needed for early stratification of risk in patients who might develop heart failure after myocardial infarction. We describe a non-contrast cardiac magnetic resonance (CMR) approach for sensitive detection of myocardial fibrosis using a canine model of myocardial infarction and reperfusion.

methodsSeven dogs had coronary thrombotic occlusion of the left anterior descending coronary arteries followed by fibrinolytic reperfusion. CMR studies were performed at 7days after reperfusion. A CMR spin-locking T

resultsHistopathology of 14 myocardial tissue segments from septal regions was graded as grade 1 (fibrosis area, <20% of a low power field, n=9), grade 2 (fibrosis area, 20-50% of field, n=4), or grade 3 (fibrosis area, >50% of field, n=1). A dramatic difference in fibrosis index (183%, P<0.001) was observed by CMR from grade 1 to 2, whereas differences were much smaller for T

conclusionA non-contrast CMR index based on T

Indexed as

AnimalsDisease Models, AnimalDogsFibrosisHeartHeart FailureHumansMagnetic Resonance ImagingMyocardial InfarctionMyocardiumReproducibility of ResultsSeverity of Illness IndexCMRMyocardial diffuse fibrosisMyocardial infarctionSpin-lock T(1)ρ

Identifiers

PMID28461132
PMCPMC6294294
OpenAlexW2609472111

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.