Evidence map›Paper›PMID 28461102›Full record

ArticleNeurobiology of aging2017

Effect of caloric restriction on plasma melatonin levels in aged rhesus macaques.

Nona Aghazadeh-Sanai, Jodi L Downs, Julie A Mattison, Donald K Ingram, Steven G Kohama, Henryk F Urbanski

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurobiology of aging, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.4field-weighted citation impact, top 47% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Nona Aghazadeh-SanaiDivision of Neuroscience, Oregon National Primate Research Center, Beaverton, OR, USA.
Jodi L DownsDivision of Neuroscience, Oregon National Primate Research Center, Beaverton, OR, USA; Department of Behavioral Neuroscience, Oregon Health & Science University, Portland, OR, USA.
Julie A MattisonTranslational Gerontology Branch, Intramural Research Program, National Institute on Aging, Baltimore, MD, USA.
Donald K IngramPennington Biomedical Research Center, Louisiana State University System, Baton Rouge, LA, USA.
Steven G KohamaDivision of Neuroscience, Oregon National Primate Research Center, Beaverton, OR, USA.
Henryk F UrbanskiDivision of Neuroscience, Oregon National Primate Research Center, Beaverton, OR, USA; Department of Behavioral Neuroscience, Oregon Health & Science University, Portland, OR, USA. Electronic address: urbanski@ohsu.edu.
Oregon National Primate Research Center · USNational Institute on Aging · USPennington Biomedical Research Center · US

Funding

Upgrade of confocal microscopy at the Oregon National Primate Research CenterP51OD011092 · OD · OREGON HEALTH & SCIENCE UNIVERSITY · PI Bonnie J. Nagel · 2012 to 2026
$203.9M
Primate Aging StudiesZIAAG000371 · NIA · NATIONAL INSTITUTE ON AGING · PI MATTISON, JULIE · 2010 to 2025
$13.7M
Cognition in Rhesus Macaques in Relation to Age and Endocrine StatusR01AG036670 · NIA · OREGON HEALTH & SCIENCE UNIVERSITY · PI URBANSKI, HENRYK F · 2011 to 2015
$3.2M
Interacting Impact of Adrenal and Ovarian Aging on the CNSR01AG029612 · NIA · OREGON HEALTH & SCIENCE UNIVERSITY · PI URBANSKI, HENRYK F · 2007 to 2011
$2.4M
Effect of Aging and Caloric Restriction on Circadian Ph*R01AG019914 · NIA · OREGON HEALTH AND SCIENCE UNIVERSITY · PI URBANSKI, HENRYK F · 2001 to 2005
$1.0M
Interacting Impact of Adrenal and Ovarian Aging on the CNSR56AG029612 · NIA · OREGON HEALTH & SCIENCE UNIVERSITY · PI URBANSKI, HENRYK F · 2018 to 2018
$700k
NIA NIH HHS R01 AG019914NIA NIH HHS R01 AG029612NIA NIH HHS R01 AG036670NIA NIH HHS R56 AG029612NIH HHS P51 OD011092
6 · The paper itself

Abstract

In this study, we examined the 24-hour plasma melatonin patterns of young adult (∼11 years of age) and old (∼24 years of age) rhesus macaques, and determined how they would be influenced by 30% caloric restriction (CR). Well-defined 24-hour plasma melatonin rhythms were observed in all the males but only the old animals showed significant attenuation of night-time melatonin levels. Moreover, 4.5 years of CR failed to prevent the age-associated decline in plasma melatonin levels in the old males and caused a significant decrease in the young adult males. Similar plasma melatonin rhythms were also observed in all the females but no age-related decline was detected, and 2 years of CR had no obvious effect on plasma melatonin levels. If anything, there was a trend for the CR to decrease melatonin levels in the young adult females. Taken together, the results fail to show any clear benefit of CR on plasma melatonin levels in old rhesus macaques and may even be detrimental to plasma melatonin levels in young adults.

Indexed as

Caloric RestrictionAgingAnimalsEnergy IntakeFemaleHumansMacaca mulattaMaleMelatoninMelatoninAgingCaloric restrictionCircadianEndocrine rhythmsMelatoninPrimate

Identifiers

PMID28461102
PMCPMC5460625
OpenAlexW2605347119

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.